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Submissions from 2014

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Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior, Gabe Haller, Ping Li, Caroline Esch, Simon Hsu, Alison M. Goate, and Joe Henry Steinbach

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Relative mortality in U.S. Medicare beneficiaries with parkinson disease and hip and pelvic fractures, Marcie Harris-Hayes, Allison W. Willis, Sandra E. Klein, Sylvia Czuppon, Beth Crowner, and Brad A. Racette

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Information-seeking among chronic disease prevention staff in state health departments: use of academic journals, Jenine K. Harris, Peg Allen, Rebekah R. Jacob, Lindsay Elliott, and Ross C. Brownson

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Ureteral stent placement increases the risk for developing BK viremia after kidney transplantation., Faris Hashim, Shehzad Rehman, Jon A. Gregg, and Vikas R. Dharnidharka

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Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus, Junyun He, Huafang Lai, Michael Engle, Sergey Gorlatov, Clemens Gruber, Herta Steinkellner, Michael S. Diamond, and Qiang Chen

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Data dictionary services in XNAT and the Human Connectome Project, Rick Herrick, Michael McKay, Timothy Olsen, William Horton, Mark Florida, Charles J. Moore, and Daniel S. Marcus

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Seroepidemiology of astrovirus MLB1, Lori R. Holtz, Irma K. Bauer, Hongbing Jiang, Robert Belshe, Pamela Freiden, Stacey L. Schultz-Cherry, and David Wang

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Parallels between cancer and infectious disease, Richard S. Hotchkiss and Lyle L. Moldawer

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Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing, Andrew E. O. Hughes, Vincent Magrini, Ryan Demeter, Christopher A. Miller, Robert Fulton, Lucinda L. Fulton, William C. Eades, Kevin Elliott, Sharon Heath, Peter Westervelt, Li Ding, Donald F. Conrad, Brian S. White, Jin Shao, Daniel C. Link, John F. DiPersio, Elaine R. Mardis, Richard K. Wilson, Timothy J. Ley, Matthew J. Walter, and Timothy A. Graubert

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The bacterial amyloid curli Is associated with urinary source bloodstream infection, Chia Hung, Jonas Marschall, Carey-Ann D. Burnham, Albert S. Byun, and Jeffrey P. Henderson

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Draft genome sequence of Acetobacter aceti strain 1023, a vinegar factory isolate, John E. Hung, Christopher P. Mill, Sandra W. Clifton, Vincent Magrini, Ketaki Bhide, Julie A. Francois, Aaron E. Ransome, Lucinda Fulton, Jyothi Thimmapuram, Richard K. Wilson, and T. Joseph Kappock

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A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer, Joseph E. Ippolito and David Piwnica-Worms

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Capacity building for evidence-based decision making in local health departments: Scaling up an effective training approach, Julie A. Jacobs, Kathleen Duggan, Paul Erwin, Carson Smith, Elaine Borawski, Judy Compton, Luann D'Ambrosio, Scott H. Frank, Susan Frazier-Kouassi, Peggy A. Hannon, Jennifer Leeman, Avia Mainor, and Ross C. Brownson

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Nanoparticle incorporation of melittin reduces sperm and vaginal epithelium cytotoxicity, Andrew P. Jallouk, Kelle H. Moley, Kenan Omurtag, Grace Hu, Gregory M. Lanza, Samuel A. Wickline, and Joshua L. Hood

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Engineering recombinant orsay virus directly in the metazoan host Caenorhabditis elegans, Hongbing Jiang, Carl J. Franz, and David Wang

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Anatomic determinants of sacral dysmorphism and implications for safe iliosacral screw placement, Scott P. Kaiser, Michael J. Gardner, Joseph Liu, M. L. Chip Routt Jr., and Saam Morshed

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Rehabilitation following arthroscopic rotator cuff repair: A prospective randomized trial of immobilization compared with early motion, Jay D. Keener, Leesa M. Galatz, Georgia Stobbs-Cucchi, Rebecca Patton, and Ken Yamaguchi

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SigFuge: Single gene clustering of RNA-seq reveals differential isoform usage among cancer samples, Patrick K. Kimes, Christopher R. Cabanski, Matthew D. Wilkerson, Ni Zhao, Amy R. Johnson, Charles M. Perou, Liza Makowski, Christopher A. Maher, Yufeng Liu, J. S. Marron, and D. Neil Hayes

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TrkB agonist antibody pretreatment enhances neuronal survival and long-term sensory motor function following hypoxic ischemic injury in neonatal rats, Gab Seok Kim, Seongeun Cho, James W. Nelson, Gregory J. Zipfel, and Byung Hee Han

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Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem, Ji-Young Kim, Ana Kim, Zhong-Qiu Zhou, Xian-Yu Liu, and Zhou-Feng Chen

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Impact of host age and parity on susceptibility to severe urinary tract infection in a murine model, Kimberly A. Kline, Drew J. Schwartz, Nicole M. Gilbert, and Amanda L. Lewis

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Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci, Daniel C. Koboldt, David E. Larson, Qunyuan Zhang, Ling Lin, Li Ding, Michael D. McLellan, Michele O'Laughlin, Catrina Fronick, Lucinda L. Fulton, Vincent Magrini, Robert S. Fulton, Richard K. Wilson, and et al

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Is the relationship between binge eating episodes and personality attributable to genetic factors?, Rachel Koren, Melissa A. Munn-Chernoff, Alexis E. Duncan, Kathleen K. Bucholz, Pamela A.F. Madden, Andrew C. Heath, and Arpana Agrawal

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Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution, Nalinikanth Kotagiri and Jin-Woo Kim

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Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan, Alexander M. Kulminski, Konstantin G. Arbeev, Irina Culminskaya, Liubov Arbeeva, Svetlana V. Ukraintseva, Eric Stallard, Kaare Christensen, Nicole Schupf, Michael A. Province, and Anatoli I. Yashin

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High-throughput functional testing of ENCODE segmentation predictions, Jamie C. Kwasnieski, Christopher Fiore, Hemangi G. Chaudhari, and Barak A. Cohen

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Increased frequency of Tim-3 expressing T cells is associated with symptomatic West Nile virus infection, Marion C. Lanteri, Michael S. Diamond, Jacqueline P. Law, Glen M. Chew, Shiquan Wu, Heather C. Inglis, Derek Wong, Michael P. Busch, Philip J. Norris, and Lishomwa C. Ndhlovu

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Cortical–subcortical interactions in hypersomnia disorders: Mechanisms underlying cognitive and behavioral aspects of the sleep–wake cycle, Linda J. Larson-Prior, Yo-El Ju, and James E. Galvin

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Comparison of the stand-alone Cox-Maze IV procedure to the concomitant Cox-Maze IV and mitral valve procedure for atrial fibrillation, Christopher P. Lawrance, Matthew C. Henn, Jacob R. Miller, Laurie A. Sinn, Richard B. Schuessler, and Ralph J. Damiano Jr.

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Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice, Zhe Liang, Yan Xie, Jessica A. Dominguez, Elise R. Breed, Benyam P. Yoseph, Eileen M. Burd, Alton B. Farris, Nicholas O. Davidson, and Craig M. Coopersmith

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High level expression of a glutamate-gated chloride channel gene in reproductive tissues of Brugia malayi may explain the sterilizing effect of ivermectin on filarial worms, Ben Wen Li, Amy C. Rush, and Gary J. Weil

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A gene-based analysis of variants in the serum/glucocorticoid regulated kinase (SGK) genes with blood pressure responses to sodium intake: The GenSalt Study, Changwei Li, Xueli Yang, Jiang He, James E. Hixson, Dongfeng Gu, Dabeeru C. Rao, Lawrence C. Shimmin, Jianfeng Huang, Charles C. Gu, Jichun Chen, Jianxin Li, and Tanika N. Kelly

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SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons, Cong L. Li, Aruna Sathyamurthy, Anna Oldenborg, Dharmesh Tank, and Narendrakumar Ramanan

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Differential expression of miRNAs in colon cancer between African and Caucasian Americans: Implications for cancer racial health disparities, Ellen Li, Ping Ji, Nengtai Ouyang, Yuanhao Zhang, Xin Yu Wang, Deborah C. Rubin, Nicholas O. Davidson, Roberto Bergamaschi, Kenneth R. Shroyer, Stephanie Burke, Wei Zhu, and Jennie L. Williams

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Tibet Orbivirus, a novel Orbivirus species isolated from Anopheles maculatus mosquitoes in Tibet, China, Minghua Li, Yayun Zheng, Guoyan Zhao, Shihong Fu, David Wang, Zhiyu Wang, and Guodong Liang

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B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway, Xian-Yu Liu, Li Wan, Fu-Quan Huo, Devin M. Barry, Hui Li, Zhong-Qiu Zhao, and Zhou-Feng Chen

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The impact of depression and pain catastrophization on initial presentation and treatment outcomes for atraumatic hand conditions, Daniel A. London, Jeffrey G. Stepan, Martin I. Boyer, and Ryan P. Calfee

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Functional insights into modulation of BKCa channel activity to alter myometrial contractility, Ramón A. Lorca, Monali Prabagaran, and Sarah K. England

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T cell immunodominance is dictated by the positively selecting self-peptide, Wan-Lin Lo, Benjamin D. Solomon, David L. Donermeyer, Chyi-Song Hsieh, and Paul M. Allen

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Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma, Charles Lu, Li Ding, Elaine R. Mardis, Richard K. Wilson, and et al

RB1 gene inactivation by chromothripsis in human retinoblastoma, Charles Lu, Robert S. Fulton, Lucinda L. Fulton, Xin Hong, David J. Dooling, Kerri Ochoa, Elaine R. Mardis, Richard K. Wilson, and et al

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Kids, candy, brain and behavior: Age differences in responses to candy gains and losses, Katherine R. Luking, Joan L. Luby, and Deanna M. Barch

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DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML, Kirstin Lund, John J. Cole, Nathan D. VanderKraats, Tony McBryan, Nikolay A. Pchelintsev, William Clark, Mhairi Copland, John R. Edwards, and Peter D. Adams

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Decitabine in the treatment of acute myeloid leukemia in elderly patients, Priya Malik and Amanda F. Cashen

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The pitfalls of electronic health orders: Development of an enhanced institutional protocol after a preventable patient death, Brandon J. Manley, Rebecca K. Gericke, John A. Brockman, Jennifer Robles, Valary T. Raup, and Sam B. Bhayani

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Treatment approach, surveillance, and outcome of well-differentiated thyroid cancer in childhood and adolescence., Stephanie Markovina, Perry W. Grigsby, Julie K. Schwarz, Todd DeWees, Jeffrey F. Moley, Barry A. Siegel, and Stephanie M. Perkins

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Baseline hypovitaminosis D is not associated with poor clinical outcomes in osteoarticular infections, J Marschall, J. W.S. Lewis, D. K. Warren, H. M. Babcock, R. L. Barrack, and V. J. Fraser

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Slope of the anterior mitral valve leaflet: A new measurement of left ventricular unloading for left ventricular assist devices and systolic dysfunction, Sara C. Martinez, Elisa A. Bradley, Eric L. Novak, Ravi Rasalingam, Ari M. Cedars, Gregory A. Ewald, Scott C. Silvestry, and Susan M. Joseph

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Public perception regarding anterior cruciate ligament reconstruction, Matthew J. Matava, Daniel R. Howard, Landon Polakof, and Robert H. Brophy

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Economic evaluation of access to musculoskeletal care: The case of waiting for total knee arthroplasty, Richard C. Mather III, Kevin T. Hug, Lori A. Orlando, Tyler Steven Watters, Lane Koenig, Ryan M. Nunley, and Michael P. Bolognesi

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Transcription factor regulation and chromosome dynamics during pseudohyphal growth, David Mayhew and Robi D. Mitra

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Long bone structure and strength depend on BMP2 from osteoblasts and osteocytes, but not vascular endothelial cells, Sarah H. McBride, Jennifer A. McKenzie, Bronwyn S. Bedrick, Paige Kuhlmann, Jill D. Pasteris, Vicki Rosen, and Matthew J. Silva

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Macrolides are associated with a better survival rate in patients hospitalized with community-acquired but not healthcare-associated pneumonia, Colleen McEvoy, Scott T. Micek, Richard M. Reichley, Jason Kan, Alex Hoban, Justin Hoffmann, Andrew F. Shorr, and Marin H. Kollef

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Clinical implications for patients treated inappropriately for community-acquired pneumonia in the emergency department, Scott T. Micek, Adam Lang, Brian M. Fuller, Nicholas B. Hampton, and Marin H. Kollef

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In vivo evaluation of a reverse thermosensitive polymer for ureteroscopy with laser lithotripsy: Porcine model, Jonathan M. Mobley, Goutham Vemana, Marshall Strother, Robert Sherburne Figenshau, Joel M. Vetter, Jeffrey Larson, and Brian M. Benway

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Pulmonary phaeohyphomycosis caused by phaeoacremonium in a kidney transplant recipient: Successful treatment with posaconazole, Saivaralaxmi Monaganti, Carlos A Q Santos, Andrea Markwardt, Morgan A. Pence, and Daniel C. Brennan

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Soft-tissue abnormalities associated with treatment-resistant and treatment-responsive clubfoot: Findings of MRI analysis, Daniel K. Moon, Christina A. Gurnett, Hyuliya Aferol, Marilyn J. Siegel, Paul K. Commean, and Matthew B. Dobbs

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Gout in a 15-year-old boy with juvenile idiopathic arthritis: A case study, Hallie Morris, Kristen Grant, Geetika Khanna, and Andrew J. White

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CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria, Kenneth M. Murphy and et al

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Complete response and prolonged disease-free survival in a patient with recurrent duodenal adenocarcinoma treated with bevacizumab plus FOLFOX6, Gayathri Nagaraj, Yousef Zarbalian, Karin Flora, and Benjamin R. Tan Jr.

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Factors affecting outcome after structural failure of repaired rotator cuff tears, Surena Namdari, Ryan P. Donegan, Aaron M. Chamberlain, Leesa M. Galatz, Ken Yamaguchi, and Jay D. Keener

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Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to schistosomiasis, Marcia Nascimento, Stanley C. Huang, Amber Smith, Bart Everts, Wing Lam, Elizabeth Bassity, Emmanuel L. Gautier, Gwendalyn J. Randolph, and Edward J. Pearce

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Finished sequence and assembly of the DUF1220-rich 1q21 region using a haploid human genome, Majesta O'Bleness, Veronica B. Searles, C. Michael Dickens, David Astling, Derek Albracht, Angel C.Y. Mak, Yvonne Y.Y. Lai, Chin Lin, Catherine Chu, Tina Graves, Pui-Yan Kwok, Richard K. Wilson, and James M. Sikela

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Key issues and opportunities in the evolving health-care marketplace: AOA critical issues, Kristin Olds Glavin, Daniel B. Murrey, Joel C. Porter, Donald Brunn, and Rick W. Wright

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Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration, Patrick R. O'Neill and N. Gautam

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Simultaneous bilateral or unilateral carpal tunnel release? A prospective cohort study of early outcomes and limitations, Daniel A. Osei, Ryan P. Calfee, Jeffrey G. Stepan, Martin I. Boyer, Charles A. Goldfarb, and Richard H. Gelberman

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Multimeric assembly of host-pathogen adhesion complexes involved in apicomplexan invasion, May M. Paing and Niraj H. Tolia

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Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes, Pankaj Pal, Julie M. Fox, Michael S. Diamond, and et al

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Anti-angiogenesis therapy in the Vx2 rabbit cancer model with a lipase-cleavable Sn 2 taxane phospholipid prodrug using αvβ3-targeted theranostic nanoparticles, Dipanjan Pan, Anne H. Schmieder, Kezheng Wang, Xiaoxia Yang, Angana Senpan, Grace Cui, Kendall Killgore, Benjamin Kim, John S. Allen, Huiying Zhang, Shelton D. Caruthers, Baozhong Shen, Samuel A. Wickline, and Gregory M. Lanza

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Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice, Joanna E. Pankiewicz, Maitea Guridi, Jungsu Kim, Ayodeji A. Asuni, Sandrine Sanchez, Patrick M. Sullivan, David M. Holtzman, and Martin J. Sadowski

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Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer, Roheena Z. Panni, Dominic E. Sanford, Brian A. Belt, Jonathan B. Mitchem, Lori A. Worley, Brian D. Goetz, Pinku Mukherjee, Andrea Wang-Gillam, Daniel C. Link, David G. DeNardo, S. Peter Goedegebuure, and David C. Linehan

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The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice, Charlyn G. Partridge, Gloria L. Fawcett, Bing Wang, Clay F. Semenkovich, and James M. Cheverud

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The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development, Chinmoy Patra, Kelly R. Monk, and Felix B. Engel

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Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIB procollagen and down-regulation of cholesterol and lipid homeostasis, Debabrata Patra, Elizabeth DeLassus, Guosheng Liang, and Linda J. Sandell

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Methodological challenges and solutions in auditory functional magnetic resonance imaging, Jonathan E. Peelle

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Outcome for children with metastatic solid tumors over the last four decades, Stephanie M. Perkins, Eric T. Shinohara, Todd DeWees, and Haydar Frangoul

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Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: A decade of the PREDICT-HD study, Joel S. Perlmutter, Stacey Barton, Shineeka Kaye Smith, and et al

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Gait-related brain activity in people with Parkinson disease with freezing of gait, Daniel S. Peterson, Kristen A. Pickett, Ryan Duncan, Joel Perlmutter, and Gammon M. Earhart

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Increased iron sequestration in alveolar macrophages in chronic obtructive pulmonary disease, Quentin Philippot, Gaetan Deslee, Tracy L. Adair-Kirk, Jason C. Woods, Derek Byers, Susan Conradi, Sandra Dury, Jeanne Marie Perotin, Francois Lebargy, Christelle Cassan, Richard Le Naour, Michael J. Holtzman, and Richard A. Pierce

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Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis, Amelia K. Pinto, Hilario J. Ramos, Xiaobo Wu, Shilpa Aggarwal, Bimmi Shrestha, Matthew Gorman, Kristin Y. Kim, Mehul S. Suthar, John P. Atkinson, Michael Gale Jr., and Michael S. Diamond

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Routine testing for anaerobic bacteria in cerebrospinal fluid cultures improves recovery of clinically significant pathogens, Meredith E. Pittman, Benjamin S. Thomas, Meghan A. Wallace, Carol J. Weber, and Carey-Ann D. Burnham

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Streptococcus pyogenes polymyxin B-resistant mutants display enhanced exportal integrity, Gary C. Port, Luis A. Vega, Andrew B. Nylander, and Michael G. Caparon

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Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference, George S. Portugal, Ream Al-Hasani, Amanda K. Fakira, Jose L. Gonzalez-Romero, Zare Melyan, Jordan G. McCall, Michael R. Bruchas, and Jose A. Moron

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Molecularly targeted therapies in multiple myeloma, Pilar de la Puente, Barbara Muz, Feda Azab, Micah Luderer, and Abdel Kareem Azab

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Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe, Xudong Qiu, James R. Johnson, Bradley S. Wilson, Seth T. Gammon, David Piwnica-Worms, and Edward M. Barnett

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Opposing brain differences in 16p11.2 deletion and duplication carriers, Abid Y. Qureshi, Sophia Mueller, Abraham Z. Snyder, Pratik Mukherjee, Jeffrey I. Berman, Timothy P. L. Roberts, Srikantan S. Nagarajan, John E. Spiro, Wendy K. Chung, Elliott H. Sherr, and Randy L. Buckner

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Diffusion tensor imaging in children with unilateral hearing loss: A pilot study, Tara Rachakonda, Joshua S. Shimony, Rebecca S. Coalson, and Judith E.C. Lieu

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The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy, Cara Rada, Nan Lin, Sarah K. England, and et al

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AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake, Ramachandran Rashmi, Carl DeSelm, Cynthia Helms, Anne Bowcock, Buck E. Rogers, Janet Rader, Perry W. Grigsby, and Julie K. Schwarz

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IL-15 deficient Tax mice reveal a role for IL-1α in tumor immunity, Daniel A. Rauch, John C. Harding, and Lee Ratner

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Illustrated techniques for performing the Cox-Maze IV procedure through a right mini-thoracotomy, Jason O. Robertson, Lindsey L. Saint, Jeremy E. Leidenfrost, and Ralph J. Damiano Jr.

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Utilizing cytokines to function-enable human NK cells for the immunotherapy of cancer, Rizwan Romee, Jeffrey W. Leong, and Todd A. Fehniger

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Genome-wide tissue-specific gene expression, co-expression and regulation of co-expressed genes in adult nematode Ascaris suum, Bruce A. Rosa, Douglas P. Jasmer, and Makedonka Mitreva

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The role of neutrophil myeloperoxidase in models of lung tumor development, Amy Rymaszewski, Everett Tate, Joannes P. Yimbesalu, Andrew E. Gelman, Jason A. Jarzembowski, Hao Zhang, Kirkwood A. Pritchard Jr., and Haris G. Vikis

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How I do it: Minimally invasive Cox-Maze IV procedure, Lindsey L. Saint, Christopher P. Lawrance, Jeremy E. Leidenfrost, Jason O. Roberston, and Ralph J. Damiano Jr.

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Critical glycosylated residues in exon three of erythrocyte Glycophorin A engage Plasmodium falciparum EBA-175 and define receptor specificity, Nichole D. Salinas, May M. Paing, and Niraj H. Tolia

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Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis, Nayan J. Sarma, Venkataswarup Tiriveedhi, Jeffrey S. Crippin, William C. Chapman, and Thalachallour Mohanakumar

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Shiga toxin-producing Escherichia coli: A single-center, 11-year pediatric experience, Emily I. Schindler, Patricia Sellenriek, Gregory A. Storch, Phillip I. Tarr, and Carey-Ann D. Burnham

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Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and Major Depressive Disorder, Andrew J. Schrage, Michele L. Pergadia, Pamela A. F. Madden, and et al

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Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling, Rebecca C. Schugar, Ashley R. Moll, D. Andre d'Avignon, Carla J. Weinheimer, Attila Kovacs, and Peter A. Crawford