This paper studies the role of nitric oxide (NOS 1, NOS 2, and NOS 3 genes) in the mouse cochlea and in noise-induced hearing loss (NIHL). Mice genetically deficient of the NOS 2 and NOS 3 genes were protected from NIHL, indicating that one or both of these genes may be responsible for producing nitric oxide that damages the inner ear when exposed to harmful levels of noise.
Program in Audiology and Communication Sciences, Washington University School of Medicine
Hearing Loss, Noise-Induced; Nitric Oxide
Faddis, Brian; Ohlemiller, Kevin
Timmermann, Emily, "The effects of noise exposure on nitric oxide synthase knockout mice" (2002). Independent Studies and Capstones. Paper 506. Program in Audiology and Communication Sciences, Washington University School of Medicine.