Issue Date

2002

Abstract

This paper studies the role of nitric oxide (NOS 1, NOS 2, and NOS 3 genes) in the mouse cochlea and in noise-induced hearing loss (NIHL). Mice genetically deficient of the NOS 2 and NOS 3 genes were protected from NIHL, indicating that one or both of these genes may be responsible for producing nitric oxide that damages the inner ear when exposed to harmful levels of noise.

Language

English

Publisher

Program in Audiology and Communication Sciences, Washington University School of Medicine

Subject (MeSH)

Hearing Loss, Noise-Induced; Nitric Oxide

Document Type

Thesis

Advisor

Faddis, Brian; Ohlemiller, Kevin