Hair cell death and regeneration on the zebrafish posterior lateral line was investigated after cisplatin administration. Hair cell regeneration was first observed by 24 hours of recovery and was further analyzed after specific recovery intervals. Disruption of the notch signaling pathways by the y-secretase inhibitor DAPT resulted in an increase in hair cells at three days of recovery.
Program in Audiology and Communication Sciences, Washington University School of Medicine
Genualdi, Alisa A., "Cisplatin ototoxicity and hair cell regeneration in the zebrafish lateral line" (2012). Independent Studies and Capstones. Paper 646. Program in Audiology and Communication Sciences, Washington University School of Medicine.