Issue Date

2012

Abstract

Hair cell death and regeneration on the zebrafish posterior lateral line was investigated after cisplatin administration. Hair cell regeneration was first observed by 24 hours of recovery and was further analyzed after specific recovery intervals. Disruption of the notch signaling pathways by the y-secretase inhibitor DAPT resulted in an increase in hair cells at three days of recovery.

Language

English

Publisher

Program in Audiology and Communication Sciences, Washington University School of Medicine

Subject (MeSH)

Cisplatin; Zebrafish

Subject (LC)

Hair cells--Regeneration

Document Type

Thesis

Advisor

Warchol, Mark