A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity

Authors

Verena Burtscher, Washington University School of Medicine in St. Louis
Lei Wang, Washington University School of Medicine in St. Louis
John Cowgill, Stockholm University
Zi-Wei Chen, Washington University School of Medicine in St. Louis
Christopher Edge, Imperial College
Edward Smith, Imperial College
Yongchang Chang, Washington University School of Medicine in St. Louis
Lucie Delemotte, KTH Royal Institute of Technology
Alex S Evers, Washington University School of Medicine in St. Louis
Baron Chanda, Washington University School of Medicine in St. Louis

Journal

Science Advances

Publication Date

1-3-2025

Volume

11

Issue

1

First Page

eadr7427

Document Type

Open Access Publication

DOI

10.1126/sciadv.adr7427

Rights and Permissions

Burtscher V, Wang L, Cowgill J, Chen ZW, Edge C, Smith E, Chang Y, Delemotte L, Evers AS, Chanda B. A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity. Sci Adv. 2025 Jan 3;11(1):eadr7427. doi: 10.1126/sciadv.adr7427 Copyright © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. no claim to original U.S. Government Works. Distributed under a Creative Commons Attribution license 4.0 (CC BY).

Recommended Citation

Burtscher, Verena; Wang, Lei; Cowgill, John; Chen, Zi-Wei; Edge, Christopher; Smith, Edward; Chang, Yongchang; Delemotte, Lucie; Evers, Alex S; and Chanda, Baron, "A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity." Science Advances. 11, 1. eadr7427 (2025).
https://digitalcommons.wustl.edu/oa_4/4631

Additional Links

Supplemental material is available for this article at publisher site.