Journal
Journal of experimental medicine
Publication Date
6-2-2025
Volume
222
Issue
6
First Page
e20240272
Document Type
Open Access Publication
DOI
10.1084/jem.20240272
Rights and Permissions
Bradly M. Bauman, Jeffrey R. Stinson, Melissa A. Kallarakal, Lei Haley Huang, Andrew M. Frank, Gauthaman Sukumar, Nermina Saucier, Clifton L. Dalgard, Alice Y. Chan, Joshua D. Milner, Megan A. Cooper, Andrew L. Snow; Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells. J Exp Med 2 June 2025; 222 (6): e20240272. © 2025 Bauman et al. Originally published in Journal of Experimental Medicine. https://doi.org/10.1084/jem.20240272.
Recommended Citation
Bauman, Bradly M; Stinson, Jeffrey R; Kallarakal, Melissa A; Huang, Lei Haley; Frank, Andrew M; Sukumar, Gauthaman; Saucier, Nermina; Dalgard, Clifton L; Chan, Alice Y; Milner, Joshua D; Cooper, Megan A; and Snow, Andrew L, "Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells." Journal of experimental medicine. 222, 6. e20240272 (2025).
https://digitalcommons.wustl.edu/oa_4/4976
Department
ICTS (Institute of Clinical and Translational Sciences)
Table S1: Brief clinical description of patient harboring R891Q (c.2672G>A) CARD11
jem_20240272_tables2.xlsx (277 kB)
Table S2: Differentially expressed genes in wild-type Jurkat T cells stimulated with PMA/ionomycin versus unstimulated cells
jem_20240272_tables3.xlsx (55 kB)
Table S3: Differentially expressed genes in CARD11 KO Jurkat T cells stimulated with PMA/ionomycin versus wild-type Jurkat T cells stimulated with PMS/ionomycin
jem_20240272_tables4.xlsx (13 kB)
Table S4: Differentially expressed genes in wild-type Jurkat T cells stimulated with PMA/ionomycin in the presence of JNK-IN-8 versus DMSO
jem_20240272_tables5.xlsx (20 kB)
Table S5: Transcription factor activities in wild-type Jurkat T cells stimulated with PMA/ionomycin versus unstimulated cells
jem_20240272_tables6.xlsx (11 kB)
Table S6: Transcription factor activities in CARD11 KO Jurkat T cells stimulated with PMA/ionomycin versus wild-type Jurkat T cells stimulated with PMA/ionomycin
jem_20240272_tables7.xlsx (9 kB)
Table S7: Transcription factor activities in wild-type Jurkat T cells stimulated with PMA/ionomycin in the presence of JNK-IN-8 versus DMSO
jem_20240272_tables8.xlsx (19 kB)
Table S8: PBMC_Phenotype
jem_20240272_tables9.xlsx (12 kB)
Table S9: EffectorT_ Phenotype
jem_20240272_sourcedataf1.pdf (40193 kB)
SourceData F1
jem_20240272_sourcedataf2.pdf (12408 kB)
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jem_20240272_sourcedataf3.pdf (20660 kB)
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jem_20240272_sourcedataf4.pdf (7340 kB)
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jem_20240272_sourcedataf5.pdf (33822 kB)
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jem_20240272_sourcedatafs1.pdf (55279 kB)
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jem_20240272_sourcedatafs2.pdf (20356 kB)
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jem_20240272_sourcedatafs3.pdf (10905 kB)
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jem_20240272_sourcedatafs4.pdf (76510 kB)
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