Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe

Authors

Pedro Ortega, University of California
Elodie Bournique, University of California
Junyi Li, University of California
Ambrocio Sanchez, University of California
Gisselle Santiago, University of California
Brooke R Harris, Washington University School of Medicine in St. Louis
Josefine Striepen, Sloan Kettering Institute
John Maciejowski, Sloan Kettering Institute
Abby M Green, Washington University School of Medicine in St. Louis
Rémi Buisson, University of California

Journal

Science Advances

Publication Date

4-18-2025

Volume

11

Issue

16

First Page

eadu0437

Document Type

Open Access Publication

DOI

10.1126/sciadv.adu0437

Rights and Permissions

Ortega P, Bournique E, Li J, Sanchez A, Santiago G, Harris BR, Striepen J, Maciejowski J, Green AM, Buisson R. Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe. Sci Adv. 2025 Apr 18;11(16):eadu0437. doi: 10.1126/sciadv.adu0437 Copyright © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

Recommended Citation

Ortega, Pedro; Bournique, Elodie; Li, Junyi; Sanchez, Ambrocio; Santiago, Gisselle; Harris, Brooke R; Striepen, Josefine; Maciejowski, John; Green, Abby M; and Buisson, Rémi, "Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe." Science Advances. 11, 16. eadu0437 (2025).
https://digitalcommons.wustl.edu/oa_4/5065

Additional Links

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