Open Access Publication
Ransdell, Joseph L.; Moreno, Jonathan D.; Bhagavan, Druv; Silva, Jonathan R.; and Nerbonne, Jeanne M., ,"Intrinsic mechanisms in the gating of resurgent Na+ currents." Elife. 11,. . (2022).
elife-70173-sa2-fig1-v2.jpg (20 kB)
Author response image 1. Simulations of INaR following membrane depolarizations to different voltages using the open-blocked model. Left: voltage protocol indicating a 0 mV (black), -15 mV (blue), -30 mV (red), -45 mV (green) depolarization for 5 ms from a membrane potential of -90 mV. Middle: Simulated Nav current traces. Right: A zoomed in view of the simulated Nav currents reveals that the open-blocked model produces resurgent currents quite different from those observed experimentally (Figure 2A); compare with the results of the novel model generated here (Figure 3I). Additionally, INaR inactivation in this (open-blocked) model appears to show some voltage dependence, which is also not observed in our model (Figure 3I).
elife-70173-sa2-fig2-v2.jpg (64 kB)
Author response image 2
elife-70173-transrepform1-v2.pdf (211 kB)
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