Journal
Elife
Publication Date
2022
Volume
11
First Page
e74072
Document Type
Open Access Publication
DOI
10.7554/eLife.74072
Rights and Permissions
eLife 2022;11:e74072 DOI: 10.7554/eLife.74072.© 2022, Van Winkle et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Van Winkle, Jacob A.; Peterson, Stefan T.; Kennedy, Elizabeth A.; Wheadon, Michael J.; Ingle, Harshad; Desai, Chandni; Rodgers, Rachel; Constant, David A.; Wright, Austin P.; Li, Lena; Artyomov, Maxim N.; Lee, Sanghyun; Baldridge, Megan T.; and Nice, Timothy J., "Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium." Elife. 11, e74072 (2022).
https://digitalcommons.wustl.edu/open_access_pubs/11410
Figure 1—source data 1 Gene set enrichment analysis, differential gene expression analysis, and counts of homeostatic interferon-stimulated genes (ISGs) from RNA sequencing analysis.
elife-74072-fig2-data1-v2.xlsx (37 kB)
Figure 2—source data 1 Values and statistical tests of interferon-stimulated genes (ISG) expression in ileum, colon, mesenteric lymph node (MLN), and spleen.
elife-74072-fig3-data1-v2.xlsx (32 kB)
Figure 3—source data 1 Values and statistical tests of interferon-stimulated gene (ISG) expression in the ileum and colon of genetic knockout mice.
elife-74072-fig4-data1-v2.xlsx (20 kB)
Figure 4—source data 1 Values and statistical tests of interferon-stimulated gene (ISG) expression in the ileum and colon of genetic knockout mice.
elife-74072-fig5-data1-v2.xlsx (13 kB)
Figure 5—source data 1 Values and statistical tests of interferon expression by CD45+ cells in the ileum.
elife-74072-fig6-data1-v2.xlsx (11 kB)
Figure 6—source data 1 Values and statistical tests of Ifit1 area in the ileum of treated and genetic knockout mice.
elife-74072-fig7-data1-v2.xlsx (22 kB)
Figure 7—source data 1 Values and statistical tests of the percentage of cells expressing individual interferon-stimulated genes (ISGs) in single-cell RNA sequencing datasets.
elife-74072-fig8-data1-v2.xlsx (14 kB)
Figure 8—source data 1 Values and statistical tests of Ifit1 area, the proportion of Ifit1-positive cells, and 16S gene copies.
elife-74072-fig9-data1-v2.xlsx (22 kB)
Figure 9—source data 1 Values and statistical tests of murine rotavirus (mRV) genomes, percentages of cells infected, median fluorescence intensity (MFI), and % of cells mRV+ cells co-staining with Ifit1 expression.
elife-74072-transrepform1-v2.docx (111 kB)
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elife-74072-sa2-fig1-v2.jpg (19 kB)
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