Nature Communications

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ncomms11901-s1.pdf (690 kB)
Supplementary Figures 1-5 and Supplementary Tables 1-2

ncomms11901-s2.xlsx (35 kB)
Summary of killing rate and selection success for compound panel. Compounds rate of killing profiles were determined based on a comparison analysis to fast (chloroquine - CQ), moderate (pyrimethamine - PYR), and slow (atovaquone - ATQ) compounds profiles. Time length to obtain mutants was analyzed, with 0-50 days, 50-125 days, and > 125 days corresponding to short, moderate, and long, respectively. Selection success was quantified by the generation of resistant mutations with an EC50 fold shift {greater than or equal to} 2. Compounds with successful selections are highlighted in green. Two compounds are noted as having NA selection success, as they were removed from the study due to cross-resistance with a strain generated in this study (MMV028895) or compound instability (MMV665824).

ncomms11901-s3.xlsx (50 kB)
Whole genome sequencing summary for MMV008149.

ncomms11901-s4.xlsx (74 kB)
Raw EC50 and Hill-Slope Data for strains analyzed in a hypoxanthine 48-hour assay with synchronized parasites in a 96-well format.

ncomms11901-s5.xlsx (82 kB)
Raw EC50 and Hill-Slope Data for strains analyzed in a SYBR Green 72-hour assay with synchronized parasites in a 384-well format.

ncomms11901-s6.xlsx (71 kB)