Open Access Publication
Randolph, Gwendalyn J. and et al, ,"Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability." Nature Communications.7,. 11853. (2016).
Supplementary Figures 1-21, Supplementary Tables 1-6 and Supplementary References
ncomms11853-s1.avi (61442 kB)
Endothelial lineage-derived Yfp+ cells undergo EndMT and give rise to Fap+ fibroblast-like cells within intimal plaques. Immunofluorescence confocal microscopy with z-stack acquisition of a thoracic aortic section from a tamoxifen-induced end. SclCreERT;R26RstopYfp;ApoE-/- mice fed with 30 weeks of HFD revealed intimal plaque Yfp+ cells co-expressing the fibroblast marker Fap. Movie corresponds to the same section as displayed in Fig. 2c.
ncomms11853-s2.avi (61442 kB)