Proteomic and phosphoproteomic analysis reveals that neurokinin-1 receptor (NK1R) blockade with aprepitant in human keratinocytes activates a distinct subdomain of EGFR signaling: Implications for the anti-pruritic activity of NK1R antagonists

Authors

Shawn G Kwatra, Johns Hopkins University
Emily Boozalis, Johns Hopkins University
Amy H Huang, Johns Hopkins University
Cory Nanni, Duke University
Raveena Khanna, Johns Hopkins University
Kyle A Williams, Johns Hopkins University
Yevgeniy R Semenov, Washington University School of Medicine in St. Louis
Callie M Roberts, Duke University
Robert F Burns, Duke University
Madison Krischak, Duke University
Madan M Kwatra, Duke University

Journal

Medicines (Basel)

Publication Date

2019

Volume

6

Issue

4

First Page

114

Document Type

Open Access Publication

DOI

10.3390/medicines6040114

Rights and Permissions

Kwatra SG, Boozalis E, Huang AH, Nanni C, Khanna R, Williams KA, Semenov YR, Roberts CM, Burns RF, Krischak M, Kwatra MM. Proteomic and Phosphoproteomic Analysis Reveals that Neurokinin-1 Receptor (NK1R) Blockade with Aprepitant in Human Keratinocytes Activates a Distinct Subdomain of EGFR Signaling: Implications for the Anti-Pruritic Activity of NK1R Antagonists. Medicines. 2019; 6(4):114. doi: 10.3390/medicines6040114.

Recommended Citation

Kwatra, Shawn G; Boozalis, Emily; Huang, Amy H; Nanni, Cory; Khanna, Raveena; Williams, Kyle A; Semenov, Yevgeniy R; Roberts, Callie M; Burns, Robert F; Krischak, Madison; and Kwatra, Madan M, "Proteomic and phosphoproteomic analysis reveals that neurokinin-1 receptor (NK1R) blockade with aprepitant in human keratinocytes activates a distinct subdomain of EGFR signaling: Implications for the anti-pruritic activity of NK1R antagonists." Medicines (Basel). 6, 4. 114 (2019).
https://digitalcommons.wustl.edu/open_access_pubs/8628