Attenuated herpes simplex virus 1 (HSV-1) expressing a mutant form of ICP6 stimulates a strong immune response that protects mice against HSV-1-induced corneal disease

David J. Davido, University of Kansas
Eleain M. Tu, Washington University School of Medicine in St. Louis
Hong Wang, Washington University School of Medicine in St. Louis
Maria Korom, Washington University School of Medicine in St. Louis
Andreu Gazquez Casals, Washington University School of Medicine in St. Louis
P. Jahnu Reddy, Washington University School of Medicine in St. Louis
Heba H. Mostafa, University of Kansas
Benjamin Combs, University of Kansas
Steve D. Haenchen, University of Kansas
Lynda A. Morrison, Washington University School of Medicine in St. Louis

Abstract

We previously isolated a herpes simplex virus 1 (HSV-1) mutant, KOS-NA, that carries two nonsynonymous mutations in