Variant R94C in TNNT2‐encoded troponin T predisposes to pediatric restrictive dardiomyopathy and sudden death through impaired thin filament relaxation resulting in myocardial diastolic dysfunction

Authors

Jordan E Ezekian, Duke University
Sarah R Clippinger, Washington University School of Medicine in St. Louis
Jaquelin M Garcia, Washington University School of Medicine in St. Louis
Qixin Yang, Duke University
Susan Denfield, Baylor College of Medicine
Aamir Jeewa, The Hospital for Sick Children Toronto
William J Dreyer, Baylor College of Medicine
Wenxin Zou, Baylor College of Medicine
Yuxin Fan, Baylor College of Medicine
Hugh D Allen, Baylor College of Medicine
Jeffrey J Kim, Baylor College of Medicine
Michael J Greenberg, Washington University School of Medicine in St. Louis
Andrew P Landstrom, Duke University

Journal

Journal of the American Heart Association

Publication Date

3-3-2020

Volume

9

Issue

5

First Page

e015111

Document Type

Open Access Publication

DOI

10.1161/JAHA.119.015111

Rights and Permissions

Ezekian JE, Clippinger SR, Garcia JM, Yang Q, Denfield S, Jeewa A, Dreyer WJ, Zou W, Fan Y, Allen HD, Kim JJ, Greenberg MJ, Landstrom AP. Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction. J Am Heart Assoc. 2020 Mar 3;9(5):e015111. doi: 10.1161/JAHA.119.015111. © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

Recommended Citation

Ezekian, Jordan E; Clippinger, Sarah R; Garcia, Jaquelin M; Yang, Qixin; Denfield, Susan; Jeewa, Aamir; Dreyer, William J; Zou, Wenxin; Fan, Yuxin; Allen, Hugh D; Kim, Jeffrey J; Greenberg, Michael J; and Landstrom, Andrew P, "Variant R94C in TNNT2‐encoded troponin T predisposes to pediatric restrictive dardiomyopathy and sudden death through impaired thin filament relaxation resulting in myocardial diastolic dysfunction." Journal of the American Heart Association. 9, 5. e015111 (2020).
https://digitalcommons.wustl.edu/open_access_pubs/9016