Supporting cell proliferation patterns were assessed in the three most posterior neuromasts of zebrafish larvae following treatment with 1000 μM cisplatin. Proliferation was upregulated 48 to 72 hours post-exposure, but survival of internal supporting cell progeny was low three days after treatment. This finding may account for why hair cell regeneration is delayed or absent after cisplatin administration.
Program in Audiology and Communication Sciences, Washington University School of Medicine
Cisplatin/toxicity; Hair Cells, Auditory
Street, Laura G., "Progenitor activity within the zebrafish lateral line following cisplatin toxicity" (2013). Independent Studies and Capstones. Paper 675. Program in Audiology and Communication Sciences, Washington University School of Medicine.