Potent Dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagement

Authors

Melissa A. Edeling, Washington University School of Medicine in St. Louis
S. Kyle Austin, Washington University School of Medicine in St. LouisFollow
Bimmi Shrestha, Washington University School of Medicine in St. Louis
Kimberly A. Dowd, National Institutes of Health, BethesdaFollow
Swati Mukherjee, National Institutes of Health, Bethesda
Christopher A. Nelson, Washington University School of Medicine in St. Louis
Syd Johnson, MacroGenics, Rockville
Manu N. Mabila, Integral Molecular, Philadelphia
Elizabeth A. Christian, Integral Molecular, Philadelphia
Joseph Rucker, Integral Molecular, Philadelphia
Theodore C. Pierson, National Institutes of Health, Bethesda
Michael S. Diamond, Washington University School of Medicine in St. LouisFollow
Daved H. Fremont, Washington University School of Medicine in St. LouisFollow

Journal

PLoS Pathogens

Publication Date

2014

Volume

10

Issue

4

Inclusive Pages

e1004072

Document Type

Open Access Publication

DOI

10.1371/journal.ppat.1004072

Rights and Permissions

Edeling MA, Austin SK, Shrestha B, Dowd KA, Mukherjee S, et al. (2014) Potent Dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagement. PLoS Pathog 10(4): e1004072. doi: 10.1371/journal.ppat.1004072

Recommended Citation

Edeling, Melissa A.; Austin, S. Kyle; Shrestha, Bimmi; Dowd, Kimberly A.; Mukherjee, Swati; Nelson, Christopher A.; Johnson, Syd; Mabila, Manu N.; Christian, Elizabeth A.; Rucker, Joseph; Pierson, Theodore C.; Diamond, Michael S.; and Fremont, Daved H., "Potent Dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagement." PLoS Pathogens. 10, 4. e1004072. (2014).
https://digitalcommons.wustl.edu/open_access_pubs/2817