Environmental Enteric Dysfunction: Advancing Current Knowledge

Gut dysfunction in children in resource-poor environments is well documented. Major consequences of this dysfunction have been postulated, the most critical of which is poor growth, especially stunting. In this project, we have collated the recent published literature with the purpose of guiding near-term research into the causes and pathophysiology of enteric dysfunction.

This work was generously supported by the Bill & Melinda Gates Foundation www.gatesfoundation.org.

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Environmental enteric dysfunction: Advancing current knowledge

Donna M. Denno, Kelley M. VanBuskirk, Zakia C. Nelson, Christine A. Musser, and Phillip I. Tarr
Front Matter

Donna M. Denno, Kelley M. VanBuskirk, Zakia C. Nelson, Christine A. Musser, and Phillip I. Tarr

The front matter contains the title page, table of contents, list of tables, list of figures, list of appendices, acknowledgements, abbreviations and synopsis.
Chapter One. Environmental enteric dysfunction (EED) background

Donna M. Denno, Kelley M. VanBuskirk, Zakia C. Nelson, Christine A. Musser, and Phillip I. Tarr

1.1 EED History and Overview

1.2 An Old Problem Requiring New Knowledge

1.3 Pathophysiologic Processes and Consequences of EED

1.4 The Role of Biomarkers and Diagnostics in EED

1.5 Scientific Basis for this Review
Chapter Two. Methodology: Building the EED library and undertaking a systematic review of EED biomarkers/diagnostics

Donna M. Denno, Kelley M. VanBuskirk, Zakia C. Nelson, Christine A. Musser, and Phillip I. Tarr

2.1 EED: A Broad Field, Many Unanswered Questions

2.2 Constructing a Systematic Search Strategy Optimizing Sensitivity

2.3 Reference Volume Mitigation

2.4 Building the EED Library
Chapter Three. EED library as a basis for systematic reviews

Donna M. Denno, Kelley M. VanBuskirk, Zakia C. Nelson, Christine A. Musser, and Phillip I. Tarr

3.1 Defining Systematic Review Question Priorities

3.2 Determining Relevance to the Systematic Review

3.3 Acquisition of References and Copyright Fair Use Compliance

3.4 Documenting Relevance to the Systematic Review

3.5 Data Extraction for the Systematic Review

3.6 EED Library: Search Results Overview

3.7 Quality Control

3.8 EED Library Status
Chapter Four. Systematic review of EED biomarkers/diagnostic tests results synopsis

Donna M. Denno, Kelley M. VanBuskirk, Zakia C. Nelson, Christine A. Musser, and Phillip I. Tarr

4.1 Biomarkers and Diagnostics Systematic Search Results

4.2 Characteristics of References Included in the Systematic Review

4.3 Classification of Biomarkers and Diagnostic Tests
Chapter Five. Systematic review results by biomarker classifications

Donna M. Denno, Kelley M. VanBuskirk, Zakia C. Nelson, Christine A. Musser, and Phillip I. Tarr

5.1 Markers of Absorption and Permeability Overview

5.2 Markers of Absorption

5.3 Markers of Permeability

5.4 Markers of Digestion

5.5 Markers of Intestinal Inflammation and Intestinal Immune Activation

5.6 Markers of Systemic Inflammation and Systemic Immune Activation

5.7 Markers of Microbial Drivers

5.8 Markers of Nonspecific Intestinal Injury

5.9 Markers of Extra-Small Intestinal Function

5.10 Relationships Between Markers of EED, Including Histopathology

5.11 Relationships between EED Biomarkers and Growth or Other Outcomes of Interest
Chapter Six. Conclusions and future implications

Donna M. Denno, Kelley M. VanBuskirk, Zakia C. Nelson, Christine A. Musser, and Phillip I. Tarr

6.1 Summary of Findings

6.2 Future Biomarker and Diagnostics Research
Appendices

Donna M. Denno, Kelley M. VanBuskirk, Zakia C. Nelson, Christine A. Musser, and Phillip I. Tarr
References

Donna M. Denno, Kelley M. VanBuskirk, Zakia C. Nelson, Christine A. Musser, and Phillip I. Tarr