DOI

10.1016/j.kint.2016.12.021

Document Type

Open Access Publication

Journal

Kidney international

Volume

91

Issue

6

Inclusive Pages

1482-1494

Publication Date

2017

mmc1.docx (14 kB)
Proportion of the association mediated by acute kidney injury (N = 144,302).

mmc2.docx (16 kB)
Duration of proton pump inhibitor exposure and risk of chronic renal outcomes without acute kidney injury.

mmc3.docx (17 kB)
Relationship between proton pump inhibitor use and chronic renal outcomes in the absence of intervening acute kidney injury where acute kidney injury was defined according to the modified NHS England acute kidney injury algorithm (cohort participants were censored at the time of acute kidney injury occurrence [N = 146,224]).

mmc4.docx (16 kB)
Relationship between proton pump inhibitor use and chronic renal outcomes in the absence of intervening acute kidney injury (AKI) where AKI was defined according to the KDIGO definition (cohort participants were censored at the time of AKI occurrence [N = 148,358]).

mmc5.docx (17 kB)
Relationship between proton pump inhibitor use and chronic renal outcomes in the absence of intervening acute kidney injury (AKI) where AKI was defined by inpatient International Classification of Diseases, Ninth Revision diagnosis codes (cohort participants were censored at the time of AKI occurrence [N = 148,721]).

mmc6.docx (14 kB)
Relationship between proton pump inhibitor use and chronic renal outcomes in the absence of intervening acute kidney injury (AKI) where exposure was treated as time dependent (cohort participants were censored at the time of AKI occurrence [N = 159,647]).

mmc7.docx (14 kB)
Relationship between proton pump inhibitor use and chronic renal outcomes in the absence of intervening acute kidney injury (AKI) where variables are time dependent (cohort participants were censored at the time of AKI occurrence [N = 144032]).

mmc8.docx (14 kB)
Association of proton pump inhibitor and risk of renal outcomes in the absence of acute kidney injury (AKI) based on the Fine and Gray model in which death and AKI were considered competing risks (N = 144,032).

mmc9.docx (14 kB)
Association of proton pump inhibitor and risk of renal outcomes in the absence of acute kidney injury using an instrumental variable approach (N = 132,314).

mmc10.docx (15 kB)
High-dimensional propensity score models for the association of proton pump inhibitor and risk of chronic renal outcomes in the absence of acute kidney injury (N = 144,032).

mmc11.docx (14 kB)
Association of proton pump inhibitor and risk of renal outcomes in the absence of acute kidney injury in those without gastrointestinal conditions (N = 87,302).

mmc12.docx (14 kB)
Association of proton pump inhibitor and risk of renal outcomes in the absence of acute kidney injury in models additionally controlling for HbA1c level (N = 74,802).

mmc13.docx (14 kB)
Association of proton pump inhibitor and risk of renal outcomes in the absence of acute kidney injury in models additionally controlling for the microalbumin/creatinine ratio (N = 18,871).

mmc14.docx (14 kB)
Association of proton pump inhibitor and risk of renal outcomes in the absence of acute kidney injury in a subcohort of participants with a microalbumin/creatinine ratio <30 mg/g (N = 15,235).

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