Dissociation of LFP power and tuning in the frontal cortex during memory

Charles D. Holmes, Washington University School of Medicine in St. Louis
Charalampos Papadimitriou, Washington University School of Medicine in St. Louis
Lawrence H. Snyder, Washington University School of Medicine in St. Louis

Abstract

Working memory, the ability to maintain and manipulate information in the brain, is critical for cognition. During the memory period of spatial memory tasks, neurons in the prefrontal cortex code for memorized locations via persistent, spatially tuned increases in activity. Local field potentials (LFPs) are understood to reflect summed synaptic activity of local neuron populations and may offer a window into network-level processing. We recorded LFPs from areas 8A and 9/46 while two male cynomolgus macaques (