A human STAT1 gain-of-function mutation impairs CD8+ T cell responses against gammaherpesvirus 68

Wei Qian, Washington University School of Medicine in St. Louis
Cathrine A. Miner, Washington University School of Medicine in St. Louis
Harshad Ingle, Washington University School of Medicine in St. Louis
Derek J. Platt, Washington University School of Medicine in St. Louis
Megan T. Baldridge, Washington University School of Medicine in St. Louis
Jonathan J. Miner, Washington University School of Medicine in St. Louis

Abstract

Autosomal dominant STAT1 mutations in humans have been associated with chronic mucocutaneous candidiasis (CMC), as well as with increased susceptibility to herpesvirus infections. Prior studies have focused on mucosal and Th17-mediated immunity against