Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting

Authors

• Xi Lin, Harvard University
• Chloe Hyun-Jung Lee, University of Oxford
• Ting Zhang, Washington University School of Medicine in St. Louis
• Agne Antanaviciute, University of Oxford
• Thomas Hanley, Harvard University
• Jonathan N Glickman, Harvard University
• Nikhila S Bharadwaj, University of Wisconsin-Madison
• Vicki Rosen, Harvard University
• Jenny E Gumperz, University of Wisconsin-Madison
• Matthew K Waldor, Harvard University
• Alison Simmons, University of Oxford
• Thomas Gensollen, Université de Toulouse
• Richard S Blumberg, Harvard University

Journal

Nature Communications

Publication Date

5-6-2026

Volume

17

Issue

1

First Page

6104

Document Type

Open Access Publication

DOI

10.1038/s41467-026-72734-9

Rights and Permissions

Lin, X., Lee, C.HJ., Zhang, T. et al. Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting. Nat Commun 17, 6104 (2026). https://doi.org/10.1038/s41467-026-72734-9 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Lin, Xi; Lee, Chloe Hyun-Jung; Zhang, Ting; Antanaviciute, Agne; Hanley, Thomas; Glickman, Jonathan N; Bharadwaj, Nikhila S; Rosen, Vicki; Gumperz, Jenny E; Waldor, Matthew K; Simmons, Alison; Gensollen, Thomas; and Blumberg, Richard S, "Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting." Nature Communications. 17, 1. 6104 (2026).
https://digitalcommons.wustl.edu/oa_4/7278

Additional Links

Supplemental material is available for this article at publisher site.