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Submissions from 2024

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Saponin TQL1055 adjuvant-containing vaccine confers protection upon Mycobacterium tuberculosis challenge in mice, Mushtaq Ahmed, Eric Farris, Rosemary V Swanson, Shibali Das, Yan Yang, Tyler Martin, and Shabaana A Khader

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The association of caregiver attitudes, information sources, and trust with HPV vaccine initiation among adolescents, Akila Anandarajah, Thembekile Shato, Sarah Humble, Alan R Barnette, Heather M Brandt, Lisa M Klesges, Vetta L Sanders Thompson, and Michelle I Silver

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Lower-intensity CPX-351 plus venetoclax induction for adults with newly diagnosed AML unfit for intensive chemotherapy, Geoffrey L Uy, Vinod Pullarkat, Praneeth Baratam, Robert K Stuart, Roland B Walter, Eric S Winer, Qi Wang, Stefan Faderl, Divya Chakravarthy, Diane Menno, Ronald S Cheung, and Tara L Lin

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Molecular insights into the interaction between a disordered protein and a folded RNA, Rishav Mitra, Emery T Usher, Selin Dedeoğlu, Matthew J Crotteau, Olivia A Fraser, Neela H Yennawar, Varun V Gadkari, Brandon T Ruotolo, Alex S Holehouse, Loïc Salmon, Scott A Showalter, and James C A Bardwell

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A preoperative window-of-opportunity study of oral SERD, imlunestrant, in newly diagnosed ER-positive, HER2-negative early breast cancer: Results from the EMBER-2 study, Patrick Neven, Rebecca Aft, and et al.

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Emergent microenvironments of nucleoli, Matthew R King, Kiersten M Ruff, and Rohit V Pappu

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Inferring allele-specific copy number aberrations and tumor phylogeography from spatially resolved transcriptomics, Cong Ma, Metin Balaban, Jingxian Liu, Siqi Chen, Michael J Wilson, Christopher H Sun, Li Ding, and Benjamin J Raphael

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PET clinical study of novel antipsychotic LB-102 demonstrates unexpectedly prolonged dopamine receptor target engagement, Dean F Wong, Ganesh B Chand, Nicole Caito, Anna Eramo, Vincent T Grattan, Mark S Hixon, Ginger Nicol, Erin Lessie, Zachary Prensky, Hiroto Kuwabara, Lucy Tian, Ines Valenta, Thomas H Schindler, Gerhard Gründer, and Andrew R Vaino

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Sitravatinib in patients with solid tumors selected by molecular alterations: Results from a Phase Ib study, Lyudmila Bazhenova, Douglas R Adkins, and et al.

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TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model, Jiyoen Kim, Bakhos Tadros, Yan Hong Liang, Youngdoo Kim, Cristian Lasagna-Reeves, Jun Young Sonn, Dah-Eun Chloe Chung, Bradley Hyman, David M Holtzman, and Huda Yahya Zoghbi

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Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth, Rasha Barakat, Jit Chatterjee, Rui Mu, Xuanhe Qi, Xingxing Gu, Igor Smirnov, Olivia Cobb, Karen Gao, Angelica Barnes, Jonathan Kipnis, and David H Gutmann

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MYT1L deficiency impairs excitatory neuron trajectory during cortical development, Allen Yen, Simona Sarafinovska, Xuhua Chen, Dominic D Skinner, Fatjon Leti, MariaLynn Crosby, Jessica Hoisington-Lopez, Yizhe Wu, Jiayang Chen, Zipeng A Li, Kevin K Noguchi, Robi D Mitra, and Joseph D Dougherty

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Magrolimab plus rituximab in relapsed/refractory indolent non-Hodgkin lymphoma: 3-year follow-up of a phase 1/2 trial, Amitkumar Mehta, Leslie Popplewell, Graham P Collins, Sonali M Smith, Ian W Flinn, Nancy L Bartlett, Nilanjan Ghosh, Gal Hacohen-Kleiman, Yanan Huo, Linda Su-Feher, Camille Renard, Ranjana Advani, and Mark Roschewski

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RSK1 dependency in FLT3-ITD acute myeloid leukemia, Tim Kong, Angelo B A Laranjeira, Christopher T Letson, LaYow Yu, Fan He, Aarthi Jayanthan, Gerrit Los, Sandra E Dunn, Grant A Challen, and Stephen T Oh

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A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights, Jing Yu, Li Ding, and et al.

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Lymphocytic choriomeningitis arenavirus utilises intercellular connections for cell to cell spread, Owen Byford, Amelia B Shaw, Hiu Nam Tse, Alex Moon-Walker, Erica Ollmann Saphire, Sean P J Whelan, Martin Stacey, Roger Hewson, Juan Fontana, and John N Barr

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Mode of injury and level of synovitis alter inflammatory chondrocyte gene expression and associated pathways, Megan L Libke, Daniel J Cunningham, Bridgette D Furman, John S Yi, Jonathan M Brunger, Virginia B Kraus, Farshid Guilak, Amy L McNulty, and Steven A Olson

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Sertraline modulates hippocampal plasticity via sigma 1 receptors, cellular stress and neurosteroids, Yukitoshi Izumi, Angela M Reiersen, Eric J Lenze, Steven J Mennerick, and Charles F Zorumski

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Disordered proteins interact with the chemical environment to tune their protective function during drying, Shraddha Kc, Kenny H Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Paulette Sofia Romero-Perez, Alex S Holehouse, Shahar Sukenik, and Thomas C Boothby

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Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity, Leo I Volkov, Yohey Ogawa, Ramiz Somjee, Hannah E Vedder, Hannah E Powell, Deepak Poria, Sam Meiselman, Vladimir J Kefalov, and Joseph C Corbo

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Circulating blood circular RNA in Parkinson's disease; From involvement in pathology to diagnostic tools in at-risk individuals, Aleksandra Beric, Yichen Sun, Santiago Sanchez, Charissa Martin, Tyler Powell, Ravindra Kumar, Jose Adrian Pardo, Gauri Darekar, Jessie Sanford, Devin Dikec, Bridget Phillips, Juan A Botia, Carlos Cruchaga, and Laura Ibanez

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Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease, Anna Hofmann, Jorge J Llibre-Guerra, Richard J Perrin, Laura Ibanez, Randall J Bateman, Eric McDade, Brian A Gordon, and et al.

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A phase I first-in-human study of ABBV-011, a seizure-related homolog protein 6-targeting antibody-drug conjugate, in patients with small cell lung cancer, Daniel Morgensztern and et al.

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Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission, Anupama Tiwari, Jongyun Myeong, Arsalan Hashemiaghdam, Marion I Stunault, Hao Zhang, Xiangfeng Niu, Marissa A Laramie, Jasmin Sponagel, Leah P Shriver, Gary J Patti, Vitaly A Klyachko, and Ghazaleh Ashrafi

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In vivo evaluation of complex polyps with endoscopic optical coherence tomography and deep learning during routine colonoscopy: A feasibility study, Haolin Nie, Hongbo Luo, Vladimir Lamm, Shuying Li, Sanskar Thakur, Chao Zhou, Thomas Hollander, Daniel Cho, Erika Sloan, Jingxia Liu, Pooja Navale, Ahmad N Bazarbashi, Juan Pablo Reyes Genere, Vladimir M Kushnir, and Quing Zhu

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Behavioral and neural mechanisms of face-specific attention during goal-directed visual search, Jie Zhang, Xiaocang Zhu, Huihui Zhou, and Shuo Wang

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Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility, Ankit Garg, Silvia Jansen, Lina Greenberg, Rui Zhang, Kory J Lavine, and Michael J Greenberg

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Evaluation of prognostic factors in patients with high-risk classical Hodgkin lymphoma undergoing autologous transplantation, Narendranath Epperla, Amanda F Cashen, and et al.

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Identification and characterization of the lipoprotein N-acyltransferase in Bacteroides, Krista M Armbruster, Jiawen Jiang, Mariana G Sartorio, Nichollas E Scott, Jenna M Peterson, Jonathan Z Sexton, Mario F Feldman, and Nicole M Koropatkin

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Impact of socioeconomic deprivation on care quality and surgical outcomes for early-stage non-small cell lung cancer in United States veterans, Steven Tohmasi, Brendan T Heiden, Nikki E Rossetti, Ana A Baumann, Theodore S Thomas, Su-Hsin Chang, Nahom Seyoum, Yan Yan, Whitney S Brandt, Bryan F Meyers, Benjamin D Kozower, Varun Puri, and et al.

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An open codebase for enhancing transparency in deep learning-based breast cancer diagnosis utilizing CBIS-DDSM data, Ling Liao and Eva M Aagaard

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HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2, Venecia Alexandria Valdez, Meisheng Ma, Bernardo Gouveia, Rui Zhang, and Sabine Petry

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CRISPR/Cas9 screens identify key host factors that enhance rotavirus reverse genetics efficacy and vaccine production, Yinxing Zhu, Meagan E Sullender, Danielle E Campbell, Leran Wang, Sanghyun Lee, Takahiro Kawagishi, Gaopeng Hou, Alen Dizdarevic, Philippe H Jais, Megan T Baldridge, and Siyuan Ding

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Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade, Mayra Cruz Tleugabulova, Meizi Liu, Michael S Diamond, and et al.

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Volumetric body composition analysis of The Cancer Genome Atlas reveals novel body composition traits and molecular markers associated with renal carcinoma outcomes, Olesya Mironchuk, Andrew L Chang, Farzaneh Rahmani, Kaitlyn Portell, Elena Nunez, Zack Nigogosyan, Da Ma, Karteek Popuri, Vincent Tze Yang Chow, Mirza Faisal Beg, Jingqin Luo, and Joseph E Ippolito

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Facilitating and restraining virus infection using cell-attachable soluble viral receptors, Heng Zhang, Zhengli Wang, Huong T T Nguyen, Marjorie Cornejo Pontelli, Wanrong Qi, Liem Rao, Zhuoming Liu, Sean P J Whelan, and Jieqing Zhu

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NKp46+ ILC3s promote early neutrophil defense against Clostridioides difficile infection through GM-CSF secretion, José L Fachi, Sarah de Oliveira, Susan Gilfillan, Alina Ulezko Antonova, JinChao Hou, Marco A R Vinolo, and Marco Colonna

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Actionable structural variant detection via RNS-NGS and DNA-NGS in patients with advanced non-small cell lung cancer, Dwight Owen, Daniel Morgensztern, and et al.

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Performance of risk models for antimicrobial resistance in adult patients with sepsis, M Cristina Vazquez Guillamet, Hanyang Liu, Andrew Atkinson, Victoria J Fraser, Chenyang Lu, and Marin H Kollef

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Quality of publicly available information about urinary tract infections, Viktoria Schmitz, Zoe Troubh, Michael Durkin, Kevin Hsueh, Katheryn Ney, Brian D Carpenter, Shinbee Waldron, Mary C Politi, and CDC Prevention Epicenters Program

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Race and ethnicity, gender, and promotion of physicians in academic medicine, Lauren Clark, Elena Shergina, Nathalia Machado, Taneisha S Scheuermann, Nasrin Sultana, Deepika Polineni, Grace H Shih, Robert D Simari, Jo A Wick, and Kimber P Richter

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Race, gender, and faculty retention in academic medicine, Taneisha S Scheuermann, Lauren Clark, Nasrin Sultana, Nathalia Machado, Elena Shergina, Deepika Polineni, Grace H Shih, Robert D Simari, Jo A Wick, and Kimber P Richter

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Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection, Mark G Young, Jesús Bazan Villicana, Philippe Azimzadeh, Andrew Kau, Karen W Dodson, Henry L Schreiber 4th, Scott J Hultgren, and et al.

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Adjuvant trastuzumab emtansine versus paclitaxel plus trastuzumab for stage I human epidermal growth factor receptor 2-positive breast cancer: 5-year results and correlative analyses from ATEMPT, Paolo Tarantino, Ron Bose, and et al.

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A phase 1 first-in-human study of the MCL-1 inhibitor AZD5991 in patients with relapsed/refractory hematologic malignancies, Pinkal Desai, Amanda Cashen, and et al.

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Clinical validation of a cell-free DNA fragmentome assay for augmentation of lung cancer early detection, Peter J Mazzone, David Gierada, and et al.

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Current best practices and future opportunities for reproducible findings using large-scale neuroimaging in psychiatry, Neda Jahanshad, Petra Lenzini, and Janine Bijsterbosch

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Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages, Michael D Iglesia, Reyka G Jayasinghe, Siqi Chen, Nadezhda V Terekhanova, John M Herndon, Erik Storrs, Alla Karpova, Daniel Cui Zhou, Nataly Naser Al Deen, Andrew T Shinkle, Rita Jui-Hsien Lu, Wagma Caravan, Andrew Houston, Yanyan Zhao, Kazuhito Sato, Preet Lal, Cherease Street, Fernanda Martins Rodrigues, Austin N Southard-Smith, André Luiz N Targino da Costa, Houxiang Zhu, Chia-Kuei Mo, Lisa Crowson, Robert S Fulton, Matthew A Wyczalkowski, Catrina C Fronick, Lucinda A Fulton, Hua Sun, Sherri R Davies, Elizabeth L Appelbaum, Sara E Chasnoff, Madelyn Carmody, Candace Brooks, Ruiyang Liu, Michael C Wendl, Clara Oh, Diane Bender, Carlos Cruchaga, Oscar Harari, Andrea Bredemeyer, Kory Lavine, Ron Bose, Julie Margenthaler, Jason M Held, Samuel Achilefu, Foluso Ademuyiwa, Rebecca Aft, Cynthia Ma, Graham A Colditz, Stephen T Oh, James Fitzpatrick, Kooresh I Shoghi, Milan G Chheda, Deborah J Veis, Feng Chen, Ryan C Fields, William E Gillanders, Li Ding, and et al.

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Distinct patterns of smooth muscle phenotypic modulation in thoracic and abdominal aortic aneurysms, Chien-Jung Lin, Campbell Keating, Robyn Roth, Yasar Caliskan, Mustafa Nazzal, Vernat Exil, Richard DiPaolo, Divya Ratan Verma, Kishore Harjai, Mohamed Zayed, Chieh-Yu Lin, Robert P Mecham, and Ajay K Jain

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IGLON5 frequency in idiopathic REM sleep behavior disorder: A multicenter study, Ronald Postuma, Jennifer McLeland, Albert A. Davis, Yo-El S. Ju, and et al.

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IL-10R inhibition reprograms tumor-associated macrophages and reverses drug resistance in multiple myeloma, Jennifer Sun, Monica Shokeen, Barbara Muz, Kinan Alhallak, Chaelee Park, Berit Lubben, Yixuan Chen, Ola Adebayo, Hannah Bash, Sarah Kelley, Mark Fiala, Diane E Bender, Ravi Vij, Abdel Kareem Azab, and et al.

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Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia, Andrew Stiff, Geoffrey L Uy, and et al.

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Posttreatment surveillance intensity and overall survival in prostate cancer survivors (AFT-30), Ronald C Chen, Ramsankar Basak, Stacie Dusetzina, Deborah S Usinger, Zahed Mohammed, Aaron D Falchook, Jessica R Schumacher, Amanda B Francescatti, Amanda Cuddy, George J Chang, Benjamin D Kozower, Caprice C Greenberg, Anne K Barber, and Aaron J Katz

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Psychiatric neuroimaging designs for individualised, cohort, and population studies, Martin Gell, Stephanie Noble, Timothy O Laumann, Steven M Nelson, and Brenden Tervo-Clemmens

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Examining the impact of the QUARTET USA trial using the translational science benefits model, Guhan Iyer, Danielle Lazar, Abigail S. Baldridge, Jairo Mejia, Clara K. Chow, Namratha R. Kandula, Olutobi A. Sanuade, Linda Rosul, Jody D. Ciolino, and Mark D. Huffman

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Safety evaluations of rapamycin perfluorocarbon nanoparticles in ovarian tumor-bearing mice, Qingyu Zhou, John C Harding, Ping Fan, Ivan Spasojevic, Attila Kovacs, Antonina Akk, Adam Mitchell, Luke E Springer, Joseph P Gaut, Daniel A Rauch, Samuel A Wickline, Christine T N Pham, Katherine Fuh, and Hua Pan

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Tumour evolution and microenvironment interactions in 2D and 3D space, Chia-Kuei Mo, Jingxian Liu, Siqi Chen, Erik Storrs, Andre Luiz N Targino da Costa, Andrew Houston, Michael C Wendl, Reyka G Jayasinghe, Michael D Iglesia, John M Herndon, Austin N Southard-Smith, Jacqueline Mudd, Alla Karpova, Andrew Shinkle, S Peter Goedegebuure, Abdurrahman Taha Mousa Ali Abdelzaher, Peng Bo, Lauren Fulghum, Samantha Livingston, Angela Hill, Joseph E Ippolito, Jason M Held, Ian S Hagemann, Eric H Kim, Peter O Bayguinov, Albert H Kim, Mary M Mullen, Kooresh I Shoghi, Melissa A Reimers, Cody Weimholt, Liang-I Kang, Sidharth V Puram, Deborah J Veis, Russell Pachynski, Katherine C Fuh, Milan G Chheda, William E Gillanders, Ryan C Fields, Feng Chen, Li Ding, and et al.

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Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain, James L Shepherdson, David M Granas, Jie Li, Zara Shariff, Stephen P Plassmeyer, Alex S Holehouse, Michael A White, and Barak A Cohen

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State of the art of mobile health technologies use in clinical arrhythmia care, Arun R Sridhar, Jennifer N A Silva, and et al.

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Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency, Jianfeng Chen, Siyuan Su, Adrian Pickar-Oliver, Anna M Chiarella, Quentin Hahn, Dennis Goldfarb, Erica W Cloer, George W Small, Smaran Sivashankar, Dale A Ramsden, Michael B Major, Nathaniel A Hathaway, Charles A Gersbach, and Pengda Liu

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Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation, Rahul Chadda, Vikas Kaushik, Iram Munir Ahmad, Jaigeeth Deveryshetty, Alex S Holehouse, Snorri Th Sigurdsson, Gargi Biswas, Yaakov Levy, Brian Bothner, Richard B Cooley, Ryan A Mehl, Reza Dastvan, Sofia Origanti, and Edwin Antony

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Targeting TREM2 signaling shows limited impact on cerebrovascular calcification, Sucheta Sridhar, Yingyue Zhou, Adiljan Ibrahim, Sergio Bertazzo, Tania Wyss, Amanda Swain, Upasana Maheshwari, Sheng-Fu Huang, Marco Colonna, and Annika Keller

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An autonomous implantable device for the prevention of death from opioid overdose, Joanna L Ciatti, Victoria E Brings, Brian Ruyle, Michael R Talcott, Prashant Gupta, Richard A Slivicki, Nicolas Massaly, Michael C Montana, Mitchell Pet, Jose A Morón, Robert W Gereau, and et al.

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Multiomic and clinical analysis of multiply recurrent meningiomas reveals risk factors, underlying biology, and insights into evolution, Sangami Pugazenthi, Bhuvic Patel, William A Leidig, Kyle P McGeehan, Colin R McCornack, Shinghei Mok, Markus Anzaldua-Campos, Kaleigh Roberts, Ajay Chatrath, Hiroko Yano, Akdes S Harmanci, Akash J Patel, Albert H Kim, and et al.

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Understanding and mitigating the impact of race with adversarial autoencoders, Kathryn Sarullo and S Joshua Swamidass

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Gene-specific effects on brain volume and cognition of TMEM106B in frontotemporal lobar degeneration, Marijne Vandebergh, Nupur Ghoshal, and et al.

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Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis, Ruhang Tang, Natalia S Harasymowicz, Chia-Lung Wu, Yun-Rak Choi, Kristin Lenz, Sara J Oswald, and Farshid Guilak

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Impact of an individualized pain plan to treat sickle cell disease vaso-occlusive episodes in the emergency department, Lauren Siewny, Allison King, Cathy L Melvin, Christopher R Carpenter, Jane S Hankins, Joseph S Colla, Liliana Preiss, Lingzi Luo, Lisa Cox, Marsha Treadwell, Natalia Davila, Rita V Masese, Sarah McCuskee, S Siera Gollan, and Paula Tanabe

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Multiomics profiling of mouse polycystic kidney disease progression at a single-cell resolution, Yoshiharu Muto, Yasuhiro Yoshimura, Haojia Wu, Monica Chang-Panesso, Nicolas Ledru, Owen M Woodward, Patricia Outeda, Tao Cheng, Moe R Mahjoub, Terry J Watnick, and Benjamin D Humphreys

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SARS-CoV-2 anti-N antibodies among healthcare personnel without previous known COVID-19, Sajal Tiwary, Caroline A O'Neil, Kate Peacock, Candice Cass, Mostafa Amor, Meghan A Wallace, David McDonald, Olivia Arter, Kelly Alvarado, Lucy Vogt, Henry Stewart, Daniel Park, Victoria J Fraser, Carey-Ann D Burnham, Christopher W Farnsworth, and Jennie H Kwon

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Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice, Alexandre Gallerand, Gyu Seong Heo, Hannah Luehmann, Yongjian Liu, and et al.

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Evaluation of Ki-67 expression and large cell content as prognostic markers in MZL: A multicenter cohort study, Natalie S Grover, Marcus Watkins, Nancy L Bartlett, and et al.

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Frugal engineering-inspired wearable augmented reality goggle system enables fluorescence-guided cancer surgery, Leonid Shmuylovich, Christine M O'Brien, Karen Nwosu, and Samuel Achilefu

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A combination of four Toxoplasma gondii nuclear-targeted effectors protects against interferon gamma-driven human host cell death, Brittany Henry, Aubrey J Phillips, L David Sibley, and Alex Rosenberg

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Characterization of non-standard viral genomes during arenavirus infections identifies prominent S RNA intergenic region deletions, Matthew Hackbart and Carolina B López

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Lessons learned from the conduct of inpatient clinical trials in a pandemic, Jane A. O'Halloran, Jeremy R. Beitler, Lucy K. Chung, Mamta K. Jain, Akram Khan, Lisa H. Merck, Ahmad Mourad, Minn A. Oh, Shweta Sharma, Tammy Yokum, and Seema U. Nayak

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Social determinants of health affect psychological distress among people with disabilities, Jessica Kersey, Amie Devlin, Sarah Shyres, Emily A Kringle, and Ashley J Housten

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The utility of indocyanine green angiography in breast reconstruction to detect mastectomy skin flap necrosis and free flap perfusion: An umbrella review, Nicholas Fadell, Flora Laurent, Sai Anusha Sanka, Esther Ochoa, Lauren Yaeger, Xiaowei Li, Matthew D Wood, Justin M Sacks, and Saif Badran

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A proteomics approach to study mouse long bones: Examining baseline differences and mechanical loading-induced bone formation in young-adult and old mice, Christopher J Chermside-Scabbo, John T Shuster, Petra Erdmann-Gilmore, Eric Tycksen, Qiang Zhang, R Reid Townsend, and Matthew J Silva

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Thrombotic, cardiovascular, and microvascular complications of myeloproliferative neoplasms and clonal hematopoiesis (CHIP): A narrative review, Andrew I Schafer and Douglas L Mann

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Molecular characterization of sterol C4-methyl oxidase in Leishmania major, Yu Ning, Somrita Basu, Fong-Fu Hsu, Mei Feng, Michael Zhuo Wang, and Kai Zhang

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Recent progress in modeling and treating diabetes using stem cell-derived islets, Marlie M Maestas, Maggie H Bui, and Jeffrey R Millman

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Rethinking our future: Describing and enhancing the impacts of dissemination and implementation science for cancer prevention and control, Vianca C. Soulette, Karen M. Emmons, Douglas A. Luke, Peg Allen, Bobbi J. Carothers, and Ross C. Brownson

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Activation of PKR by a short-hairpin RNA, Kyle A Cottrell, Sua Ryu, Helen Donelick, Hung Mai, Addison A Young, Jackson R Pierce, Brenda L Bass, and Jason D Weber

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Rare variant contribution to the heritability of coronary artery disease, Ghislain Rocheleau, Erica P Young, Nathan O Stitziel, and et al.

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Symposium: What does the microbiome tell us about prevention and treatment of AD/ADRD?, Joia K Capocchi, Claudia Figueroa-Romero, Sage J B Dunham, Gina Faraci, Jason A Rothman, Katrine L Whiteson, Dong-Oh Seo, David M Holtzman, Stefanie Grabrucker, Yvonne M Nolan, Rima Kaddurah-Daouk, and David A Jett

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Association of resilience-related life experiences on variability on age of onset in dominantly inherited Alzheimer disease, Hye Joo Son, Randall J. Bateman, Jorge J. Llibre-Guerra, Richard J. Perrin, John C. Morris, Carlos Cruchaga, Jason Hassenstab, Alisha Daniels, and et al.

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Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination, Kelly L Tomaszewski, Meagan Blanchard, Reuben Olaniyi, Hannah R Brenton, Samantha Hayes, Farheen Fatma, Gaya K Amarasinghe, Byoung-Kyu Cho, Young Ah Goo, Andrea C DeDent, Stephanie A Fritz, and Juliane Bubeck Wardenburg

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Estimates of actual and potential lives saved in the United States from the use of COVID-19 convalescent plasma, Quigly Dragotakes, Jeffrey P Henderson, and et al.

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Impact of cancer therapy on clonal hematopoiesis mutations and subsequent clinical outcomes, Kevin T Nead, Irenaeus C C Chan, Kelly L Bolton, and et al.

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Informing estimates of probability of Clostridioides difficile infection for testing and treatment: Expert consensus from a modified-Delphi procedure, Jonathan D Baghdadi, Erik R Dubberke, Michael Durkin, Jennie H Kwon, and et al.

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Membrane association and polar localization of the Legionella pneumophila T4SS DotO ATPase mediated by two nonredundant receptors, Sukhithasri Vijayrajratnam, Sonja Milek, Stefano Maggi, Kaleigh Ashen, Micah Ferrell, Ahmet Hasanovic, Agnieszka Holgerson, Shanmugapriya Kannaiah, Manpreet Singh, Debnath Ghosal, Grant J Jensen, and Joseph P Vogel

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Human Epidemiology and Response to SARS-CoV-2 (HEROS): Objectives, design, and enrollment results of a 12-city remote observational surveillance study of households with children, using direct-to-participant methods, Patricia C Fulkerson, Katherine Rivera-Spoljaric, and et al.

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Xenotransplanted human organoids identify transepithelial zinc transport as a key mediator of intestinal adaptation, Maame Efua S Sampah, Vered Gazit, Deborah C Rubin, and et al.

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Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer's disease continuum, Junhao Wen, Aristeidis Sotiras, Daniel S Marcus, Pamela LaMontagne, Tammie L Benzinger, John C Morris, and et al.

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A new era of data-driven cancer research and care: Opportunities and challenges, Felicia Gomez, Arpad M Danos, Joshua F McMichael, Malachi Griffith, Obi L Griffith, and et al.

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Cell type-specific epigenetic priming of gene expression in nucleus accumbens by cocaine, Philipp Mews, Yentl Van der Zee, Ashik Gurung, Molly Estill, Rita Futamura, Hope Kronman, Aarthi Ramakrishnan, Meagan Ryan, Abner A Reyes, Benjamin A Garcia, Caleb J Browne, Simone Sidoli, Li Shen, and Eric J Nestler

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Distinct visual processing networks for foveal and peripheral visual fields, Jie Zhang, Huihui Zhou, and Shuo Wang

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Nationwide availability of and enrollment in Medicare and Medicaid dual-eligible special needs plans with exclusively aligned enrollment, Kenton J Johnston, Michelle Hendricks, Megha Dabas, Eliza Macneal, Jeah Jung, David J Meyers, Jose F Figueroa, and Eric T Roberts

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Tirzepatide prescribing practices and efficacy in patients with diabetes and chronic kidney disease at a large tertiary care center in the United States, Sriya Amruta Kosaraju and Rong M Zhang