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Submissions from 2025

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ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders, Christopher M. Sande, Karolyn A. Oetjen, Daniel C. Link, Andrew E. Gelman, Laneshia K. Tague, and et al.

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Cerebrospinal fluid proteomics identification of biomarkers for amyloid and tau PET stages, Zhibo Wang, Yuhan Chen, Katherine Gong, Bote Zhao, Yuye Ning, Meilin Chen, Yan Li, Muhammad Ali, Jigyasha Timsina, Menghan Liu, Carlos Cruchaga, and Jianping Jia

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Immunotherapeutic strategies in head and neck cancer: Challenges and opportunities, Xia Liu, R. Alex Harbison, Mark A. Varvares, Sidharth V. Puram, and Guangyong Peng

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Label-free evaluation of mouse embryo quality using time-lapse bright field and optical coherence microscopy, Fei Wang, Senyue Hao, Kibeom Park, Ali Ahmady, and Chao Zhou

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Outcomes evidence must keep up with the implementation of the 4Ms framework to ensure age-friendly health system transformation, James D Harrison, Stephanie E Rogers, Benjamin Rosner, Estelle Martin, Sunny C Lin, Jarmin Yeh, and Julia Adler-Milstein

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Synapsin condensation is governed by sequence-encoded molecular grammars, Christian Hoffmann, Kiersten M Ruff, Irina A Edu, Min Kyung Shinn, Johannes V Tromm, Matthew R King, Avnika Pant, Hannes Ausserwöger, Jennifer R Morgan, Tuomas P J Knowles, Rohit V Pappu, and Dragomir Milovanovic

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H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability, Wenxin Yuan, Yi-Chun Huang, Chantal LeBlanc, Axel Poulet, Francisca N De Luna Vitorino, Devisree Valsakumar, Renee Dean, Benjamin A Garcia, Josien C van Wolfswinkel, Philipp Voigt, and Yannick Jacob

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Left ventricular hypertrophy among adults in a population-based cohort in Haiti, Anju Ogyu, Lisa de Las Fuentes, Victor G Dávila-Román, and et al.

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Pilot first-in-human CCR2 PET/CT to detect abdominal aortic aneurysm wall instability, Santiago Elizondo-Benedetto, Deborah Sultan, Ryan Wahidi, Mahdjoub Hamdi, Mohamed S Zaghloul, Shahab Hafezi, Batool Arif, Laura K McDonald, Kitty Harrison, Dakkota Thies, Gyu Seong Heo, Hannah Luehmann, Lisa Detering, J Westley Ohman, Zachary J Wanken, Luis A Sanchez, Joseph E Ippolito, Jie Zheng, Robert J Gropler, Richard Laforest, Yongjian Liu, and Mohamed A Zayed

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The antimicrobial resistance-water-corporate interface: Exploring the connections between antimicrobials, water, and pollution, Jason P Burnham

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Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele, Xinruo Zhang, D C Rao, and et al.

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Novel recurrent cytogenetic abnormalities predict overall survival in tetraploid/near-tetraploid myelodysplastic syndrome and acute myeloid leukemia, Matthew R Avenarius, Zachary B Abrams, Ling Guo, James S Blachly, Cecelia R Miller, Nyla A Heerema, Guilin Tang, Kevin R Coombes, and Lynne V Abruzzo

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Sociodemographic differences in logins and engagement with the electronic health coach messaging feature of a mobile app to support opioid and stimulant use recovery: Results from a 1-month observational study, Lindsey M Filiatreau, Hannah Szlyk, Alex T Ramsey, Erin Kasson, Xiao Li, Zhuoran Zhang, and Patricia Cavazos-Rehg

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The human brainstem's red nucleus was upgraded to support goal-directed action, Samuel R Krimmel, Timothy O Laumann, Roselyne J Chauvin, Tamara Hershey, Jarod L Roland, Joshua S Shimony, Jon T Willie, Scott A Norris, Scott Marek, Andrew N Van, Anxu Wang, Julia Monk, Kristen M Scheidter, Forrest I Whiting, Nadeshka Ramirez-Perez, Athanasia Metoki, Noah J Baden, Benjamin P Kay, Hadas Nahman-Averbuch, Abraham Z Snyder, Marcus E Raichle, Evan M Gordon, Nico U F Dosenbach, and et al.

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Activation of endoplasmic reticulum-localized metabotropic glutamate receptor 5 (mGlu5) triggers calcium release distinct from cell surface counterparts in striatal neurons, Yuh-Jiin I Jong, Steven K Harmon, and Karen L O'Malley

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Co-designing a web-based and tablet app to evaluate clinical outcomes of early psychosis service users in a learning health care network: User-centered design workshop and pilot study, Kathleen E Burch, Adam B Wilcox, and et al.

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GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau, Diana Acosta Ingram, Jacob Marsh, Celeste M Karch, and et al.

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Impact of perioperative organ injury on morbidity and mortality in 28 million surgical patients, Felix Kork, Yafen Liang, Adit A Ginde, Xiaoyi Yuan, Rolf Rossaint, Hongfang Liu, Alex S Evers, and Holger K Eltzschig

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Investigation of the Cyanothece nitrogenase cluster in Synechocystis: A blueprint for engineering nitrogen-fixing photoautotrophs, Deng Liu, Anindita Bandyopadhyay, Michelle Liberton, Himadri B Pakrasi, and Maitrayee Bhattacharyya-Pakrasi

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Molecular subtyping of hypertensive disorders of pregnancy, Michal A Elovitz, Antonia I Frolova, and et al.

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Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension, Janelle N Posey, Mariah Jordan, Caitlin V Lewis, Christina Sul, Evgenia Dobrinskikh, Delaney Swindle, Frederik Denorme, David Irwin, Jorge Di Paola, Kurt Stenmark, Eva S Nozik, and Cassidy Delaney

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Loss of Atg7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control, Zhangying Cai, Shoutang Wang, Siyan Cao, Yun Chen, Silvia Penati, Vincent Peng, Carla M Yuede, Wandy L Beatty, Kent Lin, Yiyang Zhu, Yingyue Zhou, and Marco Colonna

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Shared pathway of WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2, Suin Jo, Ray A Ohara, Derek J Theisen, Sunkyung Kim, Tiantian Liu, Christopher B Bullock, Michelle He, Feiya Ou, Jing Chen, Sytse J Piersma, J Luke Postoak, Wayne M Yokoyama, Michael S Diamond, Theresa L Murphy, and Kenneth M Murphy

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Backbone-mediated weakening of pairwise interactions enables percolation in peptide-based mimics of protein condensates, Xiangze Zeng and Rohit V Pappu

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Comparing Analgesic Regimen Effectiveness and Safety after Surgery (CARES): Protocol for a pragmatic, international multicentre randomised trial, Mark C Bicket, Karim Shiraz Ladha, Simon Haroutounian, Kellie McFarlin, Mary Neff, Rachel L McDuffie, Jennifer F Waljee, Duminda Nalaka Wijeysundera, Chad Brummet, Yi Li, and CARES Investigators

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Responsible sharing of qualitative research data: Insights from a pioneering project in the United States, Heidi A. Walsh, Meredith V. Parsons, Jessica Mozersky, Aditi Gupta, Albert M. Lai, Annie B. Friedrich, and James M. DuBois

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Year 1 of Medicare's Accountable Care Organization Realizing Equity, Access, and Community Health model, Gmerice Hammond, Sunny Lin, Sukruth A Shashikumar, R J Waken, Fengxian Wang, Khavya Avula, Vi-Anh Hoang, Kenton J Johnston, and Karen Joynt Maddox

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Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect, Joseph Cichon, Thomas T Joseph, Xinguo Lu, Andrzej Z Wasilczuk, Max B Kelz, Steven J Mennerick, Charles F Zorumski, and Peter Nagele

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Open access dataset and common data model for pulse oximeter performance data, Nicholas Fong, Leonid Shmuylovich, and et al.

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Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition, Jun Pyo Kim, Carlos Cruchaga, and et al.

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Unraveling the complexities of myeloid-derived suppressor cells in inflammatory bowel disease, Yangzhuangzhuang Zhu and Siyan Cao

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Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination, Jinchao Hou, Roberta Magliozzi, Yun Chen, Junjie Wu, John Wulf II, Gregory Strout, Xiangming Fang, and Marco Colonna

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Antibody responses in Klebsiella pneumoniae bloodstream infection: A prospective cohort study, Wontae Hwang, Paeton L Wantuch, David A Rosen, and et al.

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Applying results of extended genotyping to management of positive cervicovaginal human papillomavirus test results: Enduring guidelines, L. Stewart Massad, Megan A. Clarke, Rebecca B. Perkins, Francisco Garcia, David Chelmow, Li C. Cheung, Teresa M. Darragh, Didem Egemen, Thomas S. Lorey, Ritu Nayar, Morgan Newman, Carolann Risley, Robert A. Smith, Nicolas Wentzensen, and Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee

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BCL-XL protects ASS1-deficient cancers from arginine starvation-induced apoptosis, Prashanta Kumar Panda, Ana Carolina Paschoalini Mafra, Alliny C S Bastos, Li Cao, Maria Serra Bonet, Caitlyn B Brashears, Ethan Yang Chen, Heather M Benedict-Hamilton, William Ehrhardt, John Bomalaski, Carina Dehner, Leonard C Rogers, Toshinao Oyama, and Brian A Van Tine

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Biliary metaplasia and macrophage activation define the cellular landscape of cardiogenic liver disease, Arick C Park, Christina F Fu, Adeesh Parvathaneni, Bin Q Yang, Mandy M Chan, Kathleen Byrnes, and Joel D Schilling

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Dynamic femoral head coverage following periacetabular osteotomy for developmental dysplasia of the hip, Christina A Bourantas, Emma C Behrman, Molly C Shepherd, Keith R Lohse, John C Clohisy, and Michael D Harris

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Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels, Sun-Joo Lee, Jian Gao, Ellen Thompson, Jonathan Mount, and Colin G Nichols

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Engineering adhesive hydrogels for hemostasis and vascular repair, Juya Jeon, Shri Venkatesh Subramani, Kok Zhi Lee, Santiago Elizondo-Benedetto, Mohamed Adel Zayed, and Fuzhong Zhang

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Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression, Anna Rea, Bishan Bhattarai, Marco Colonna, and et al.

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Factors associated with shock at presentation in Kawasaki disease versus multisystem inflammatory syndrome in children associated with Covid-19, Supriya S Jain, William B Orr, and et al.

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Femoral nail and cement static spacer technique for the treatment of chronic periprosthetic knee infection, Katherine Mistretta, Caroline Granger, Joseph Kromka, and Andrew M Schneider

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First-in-human phase I study of a CD16A bispecific innate cell engager, AFM24, targeting EGFR-expressing solid tumors, Anthony El-Khoueiry, Todd A Fehniger, Mark Foster, Melissa M Berrien-Elliott, and et al.

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Gene expression differences associated with alcohol use disorder in human brain, Caryn Willis, Julie D White, Melyssa S Minto, Bryan C Quach, Shizhong Han, Ran Tao, Joo Heon Shin, Amy Deep-Soboslay, Thomas M Hyde, R Dayne Mayfield, Bradley T Webb, Eric O Johnson, Joel E Kleinman, Laura J Bierut, and Dana B Hancock

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Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes, Michael C Sierant, Sheng Chih Jin, and et al.

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Hypertension diagnosis and management in Bamako, Mali, Issiaka Camara, Mohamed Traore, Mamoudou Maiga, Dike Ojji, Jane Holl, Souleymane Coulibaly, and Mark D Huffman

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Long-term results of bone-patellar tendon-bone versus hamstring tendon autograft for primary anterior cruciate ligament reconstruction: A meta-analysis of randomized controlled trials, Varun Gopinatth, Sina Tartibi, Matthew V Smith, Matthew J Matava, Robert H Brophy, and Derrick M Knapik

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LYSET facilitates integration of both the N- and C-terminal transmembrane helices/cytoplasmic domains of GlcNAc-1-phosphotransferase, Baraj Doray, Benjamin C Jennings, Xi Yang, Lin Liu, Varsha Venkatarangan, Stuart Kornfeld, and Ming Li

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Management aspects of medical therapy in Graves disease, Rutu Shah, Samantha E Adamson, and Sina Jasim

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Methylomic signature of current cannabis use in two first-episode psychosis cohorts, Emma L Dempster, Emma C Johnson, and et al.

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Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model, Daniyal J Jafree, Yoshiharu Muto, Benjamin D Humphreys, and et al.

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Neuroimmune mechanisms of type 2 inflammation in the skin and lung, Masato Tamari and Aaron M Ver Heul

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Patient- and community-level characteristics associated with respiratory syncytial virus vaccination, Diya Surie, Jennie H Kwon, and et al.

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Patients' attitudes to magnetic resonance imaging in perianal fistulizing Crohn's disease: A global survey, Easan Anand, Jalpa Devi, Anna Antoniou, Shivani Joshi, Jaap Stoker, Phillip Lung, Ailsa Hart, Phil Tozer, David H Ballard, and Parakkal Deepak

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Preparing to implement shared decision making in anaesthesia for hip fracture surgery: A qualitative interview study, Eliana C Goldstein, Mark D Neuman, Viktoria Vonder Haar, Aaron C Li, Carlos E Guerra-Londono, Glyn Elwyn, Stacie G Deiner, Adnan Hussain, Joshua W Sappenfield, Christopher J Edwards, Sabry Ayad, James H Baraldi, Karah Whatley, and Mary C Politi

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Quantitative and visual benefits of data-driven motion correction on oncologic PET/CT: A prospective cross-sectional study, Semra Ince, M Allan Thomas, Malak Itani, Christopher Swingle, Richard Laforest, Adeel Haq, Genevieve Muñoz, Saeed Ashrafinia, Paul Schleyer, Richard L Wahl, and Tyler J Fraum

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Racial disparities in utilization of medications and disease outcomes in inflammatory bowel disease patients, Khaled Alsabbagh Alchirazi, Osama Hamid, Thabet Qapaja, Mohammad Aldiabat, Nour Azzouz, Motasem Alkhayyat, and Miguel Regueiro

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Safety and efficacy of fecal microbiota, live-jslm, in preventing recurrent Clostridioides difficile infection in participants who were mildly to moderately immunocompromised in the phase 3 PUNCH CD3-OLS study, Carolyn D Alonso, Glenn S Tillotson, Monique R Bidell, Beth Guthmueller, Frederikke Hoeyer, Monika Fischer, and Erik R Dubberke

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SaLuDo: A randomized phase IIb/III study of lurbinectedin plus doxorubicin as first-line treatment in leiomyosarcoma, Gregory M Cote, Mia C Weiss, and et al.

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Self-collected vaginal specimens for HPV testing: Recommendations from the Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee, Nicolas Wentzensen, L. Stewart Massad, Megan A. Clarke, Francisco Garcia, Robert Smith, Jeanne Murphy, Richard Guido, Ana Reyes, Sarah Phillips, Nancy Berman, Jeffrey Quinlan, Eileen Lind, Rebecca B. Perkins, and Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee

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Severe aortic stenosis and chronic myeloid leukemia: Considerations for valve management, Rebecca Cunningham, Sang Gune K Yoo, Alexander A Brescia, Karolyn A Oetjen, Iskra Pusic, and Joshua D Mitchell

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Sexually dimorphic cardiovascular impacts of prenatal exposure to a real-life environmental chemical mixture in adult offspring, Noor Muhammad Khan, Victoria Scott, Mohammad Ghasemzadeh-Hasankolaei, Vasantha Padmanabhan, Arpita Vyas, Neil P Evans, and Michelle Bellingham

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Single-cell transcriptomic analysis of Kaposi Sarcoma, Daniel A. Rauch, Paula Valiño Ramos, Mariam Khanfar, John Harding, Ancy Joseph, Anam Fahad, Paul Simonson, Isabel Risch, Obi Griffith, Malachi Griffith, and Lee Ratner

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Statistical properties of functional connectivity MRI enrichment analysis in school-age autism research, Austin S Ferguson, Tomoyuki Nishino, Natasha Marrus, John R Pruett Jr, Alexandre A Todorov, and et al.

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Subgroup evaluation to understand performance gaps in deep learning-based classification of regions of interest on mammography, MinJae Woo, Linglin Zhang, Beatrice Brown-Mulry, InChan Hwang, Judy Wawira Gichoya, Aimilia Gastounioti, Imon Banerjee, Laleh Seyyed-Kalantari, and Hari Trivedi

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Systemic inflammation is associated with worse outcomes from SARS-CoV-2 infection but not neutralizing antibody, Christopher W Farnsworth, Brittany Roemmich, John Prostko, Gerard Davis, Gillian Murtagh, Laurel Jackson, Christopher Jacobson, Nicolette Jeanblanc, Timothy Griffiths, Edwin Frias, and David J Daghfal

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Tenapanor improves abdominal symptoms irrespective of changes in complete spontaneous bowel movement frequency in adults with irritable bowel syndrome with constipation, Darren M Brenner, Gregory S Sayuk, Brooks D Cash, Lucinda A Harris, Nitin K Ahuja, Jill K Deutsch, Yang Yang, Suling Zhao, David P Rosenbaum, and Anthony J Lembo

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The cognitive profile of older adults with treatment-resistant depression: An analysis of the OPTIMUM randomized controlled trial, Nicholas J Ainsworth, Hanadi Oughli, Helen Lavretsky, Daniel M Blumberger, Patrick J Brown, Meryl A Butters, Jordan F Karp, Emily Lenard, Eric J Lenze, Mary Pat McAndrews, J Philip Miller, Bruce G Pollock, Charles F Reynolds, and Benoit H Mulsant

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The role of androgens on experimental pain sensitivity: A systemic review and meta-analysis, Elizabeth Wu-Chen, Gourav Banerjee, Elise Requadt, Benjamin Hunter, Thomas J. Baranski, Whitney Trotter Ross, and Hadas Nahman-Averbuch

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The Ten Test and sensory evaluation of hand and finger injuries in the emergency department, Emilie H Lothet, Aaron J Lacy, and Elizabeth B Odom

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Thrombotic microangiopathy after kidney transplantation: Insights into genetic etiology and clinical outcomes, Massini Merzkani, Nyein Chann Wai Lynn, Karen Flores, Gaurav Rajashekar, Kristin Progar, Rowena Delos Santos, John P Atkinson, Daniel C Brennan, and Anuja Java

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Transcriptome meta-analysis uncovers cell-specific regulatory relationships in embryonic, juvenile, adult, and aged mouse lens epithelium and fibers, Matthieu Duot, Sarah Y Coomson, Sanjaya K Shrestha, M V Murali Krishna Nagulla, Yann Audic, Ruteja A Barve, Hongzhan Huang, Carole Gautier-Courteille, Luc Paillard, and Salil A Lachke

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Social determinants of health and health literacy in emergency patients with diabetic ketoacidosis, Daniel F Suarez, Ryan M Schneider, Margo Girardi, Gina LaRossa, Julianne Yeary, Taylor Kaser, Rachel Ancona, Paulina Cruz Bravo, and Richard T Griffey

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Patient selection, ventricular tachycardia substrate delineation, and data transfer for stereotactic arrhythmia radioablation: A clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society, Katja Zeppenfeld, Clifford Robinson, and et al.

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The emergence of human primordial germ cell-like cells in stem cell-derived gastruloids, Jitesh Neupane, Gabriele Lubatti, Theresa Gross-Thebing, Mayra Luisa Ruiz Tejada Segura, Richard Butler, Sargon Gross-Thebing, Sabine Dietmann, Antonio Scialdone, and M Azim Surani

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Independent origins and non-parallel selection signatures of triclabendazole resistance in Fasciola hepatica, Young-Jun Choi, Bruce A Rosa, Martha V Fernandez-Baca, Rodrigo A Ore, John Martin, Pedro Ortiz, Cristian Hoban, Miguel M Cabada, and Makedonka Mitreva

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PMP2+ Schwann cells maintain the survival of large-caliber motor axons, Mikolaj M Kozlowski, Amy Strickland, Ana Morales Benitez, Robert E Schmidt, A Joseph Bloom, Jeffrey Milbrandt, and Aaron DiAntonio

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Tumor Treating Fields therapy in platinum-resistant ovarian cancer: Results of the ENGOT-ov50/GOG-3029/INNOVATE-3 pivotal phase 3 randomized study, Ignace Vergote, Premal H Thaker, and et al.

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A network correspondence toolbox for quantitative evaluation of novel neuroimaging results, Ru Kong, Evan M Gordon, and et al.

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Cell-matrix feedback controls stretch-induced cellular memory and fibroblast activation, Yuan Hong, Xiangjun Peng, Haomin Yu, Delaram Shakiba, Yuxuan Huang, Chengqing Qu, Aliza Mujahid, Yin-Yuan Huang, Jacob A Sandler, Kenneth M Pryse, Justin M Sacks, Elliot L Elson, Guy M Genin, and et al.

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Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25, Parismita Kalita, Oam Khatavkar, Grace Uwase, Yulia Korshunova, Yuying Hu, Nicole D Wagner, Jian Xu, Jiehong Pan, Jay C Nix, Michael L Gross, Steven L Brody, Dominika Borek, Gaya K Amarasinghe, Jacqueline E Payton, and Daisy W Leung

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Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions, Suifang Mao, Michael J Holtzman, and et al.

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Tissue-resident CCR2+ macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured hearts, Yuriko Terada, Wenjun Li, Junedh M Amrute, Amit I Bery, Charles R Liu, Venkatrao Nunna, Christian Corbin Frye, Hao Dun, Andrew L Koenig, Hannah P Luehmann, Gyu Seong Heo, Macee C Owen, Alexander N Wein, Yongjian Liu, Jon H Ritter, Sumanth D Prabhu, Ruben G Nava, Andrew E Gelman, Marina Cella, Marco Colonna, Kory J Lavine, and Daniel Kreisel

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A generalized epilepsy network derived from brain abnormalities and deep brain stimulation, Gong-Jun Ji, Nico U F Dosenbach, and et al.

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Supportive supervision visits in a large community hypertension programme in Nigeria: Implementation methods and outcomes, Gabriel Lamkur Shedul, Nanna Ripiye, Erica L Jamro, Ikechukwu A Orji, Grace Julcit Shedul, Eugenia N Ugwuneji, Emmanuel Okpetu, Boni M Ale, Samuel Osagie, Abigail S Baldridge, Namratha R Kandula, Mark D Huffman, Dike Ojji, and Lisa Hirschhorn

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Failure mode and effects analysis applied to central venous catheter placement, James R Duncan, Daniel Harwood, Bruno Maranhao, Ellen Wertenberger, Jacob Grant, and Mona Ostman

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Compositional variation in eye-infiltrating immune cells distinguishes human uveitis subtypes, Christian Concepcion, Yu Xia, Yulia Korshunova, Gregory W Bligard, Amal Taylor, Michael A Paley, Philip A Ruzycki, and Lynn M Hassman

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Delivering guideline-directed medical therapy for heart failure with reduced ejection fraction as an over-encapsulated polypill: Rationale and protocol for the COMBO-HF-X pilot crossover randomised clinical trial, Colette DeJong, Mark D Huffman, Anubha Agarwal, and et al.

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Digital gait biomarkers in Parkinson's disease: Susceptibility/risk, progression, response to exercise, and prognosis, Martina Mancini, Gammon M Earhart, and et al.

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Distinct attentional characteristics of neurons with visual feature coding in the primate brain, Jie Zhang, Runnan Cao, Xiaocang Zhu, Huihui Zhou, and Shuo Wang

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M3NetFlow: A multi-scale multi-hop graph AI model for integrative multi-omic data analysis, Heming Zhang, S Peter Goedegebuure, Li Ding, David DeNardo, Ryan C Fields, Michael Province, Yixin Chen, Philip Payne, and Fuhai Li

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PPDPF: Preventing kidney disease through NAD+, Shin-Ichiro Imai

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Protocol to study inter-tissue communication between the hypothalamus and white adipose tissue and lifespan using a chemogenetic approach in aged mice, Kyohei Tokizane and Shin-Ichiro Imai

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Resiliency in child-caregiver dyads and the impact on health outcomes in sickle cell disease, Jessica A Zavadil, Melissa Azul, Brian D Carpenter, and Cecelia Calhoun

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Machine learning reveals distinct neuroanatomical signatures of cardiovascular and metabolic diseases in cognitively unimpaired individuals, Sindhuja Tirumalai Govindarajan, Aristeidis Sotiras, Daniel S Marcus, Pamela LaMontagne, Tammie L S Benzinger, John C Morris, and et al.

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The night's watch: Exploring how sleep protects against neurodegeneration, Samira Parhizkar and David M Holtzman

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Accelerating implementation of visual key information to improve informed consent in research: A single-institution feasibility study and implementation testing, Angela Hill, Ashley J Housten, Krista Cooksey, Eliana Goldstein, Jessica Mozersky, and Mary C Politi

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Mistargeted retinal axons induce a synaptically independent subcircuit in the visual thalamus of albino mice, Sean McCracken, Liam McCoy, Ziyi Hu, Julie A Hodges, Katia Valkova, Philip R Williams, and Josh L Morgan

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Predictors and drivers of end-of-life Medicare spending among older adults with solid tumors: A population-based study, Courtney E Baird, Elizabeth Wulff-Burchfield, Pamela C Egan, Lee A Hugar, Ami Vyas, Nikolaos A Trikalinos, Michael A Liu, Adam J Olszewski, Leonidas E Bantis, Orestis A Panagiotou, and Emmanuelle Bélanger

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The autophagy protein ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy, Pooja Popli, Arin K Oestreich, Vineet K Maurya, Marina N Rowen, Yong Zhang, Michael J Holtzman, Ramya Masand, John P Lydon, Shizuo Akira, Kelle Moley, and Ramakrishna Kommagani