LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion

Authors

Ryo Terao, Washington University School of Medicine in St. Louis
Tae Jun Lee, Washington University School of Medicine in St. Louis
Jason Colasanti, Washington University School of Medicine in St. Louis
Charles W Pfeifer, Washington University School of Medicine in St. Louis
Joseph B Lin, Washington University School of Medicine in St. Louis
Andrea Santeford, Washington University School of Medicine in St. Louis
Keitaro Hase, Washington University School of Medicine in St. Louis
Shinobu Yamaguchi, Washington University School of Medicine in St. Louis
Daniel Du, Washington University School of Medicine in St. Louis
Brian S Sohn, Washington University School of Medicine in St. Louis
Yo Sasaki, Washington University School of Medicine in St. Louis
Mitsukuni Yoshida, Washington University School of Medicine in St. Louis
Rajendra S Apte, Washington University School of Medicine in St. Louis

Journal

Cell Reports

Publication Date

5-28-2024

Volume

43

Issue

5

First Page

114102

Document Type

Open Access Publication

DOI

10.1016/j.celrep.2024.114102

Rights and Permissions

Terao R, Lee TJ, Colasanti J, Pfeifer CW, Lin JB, Santeford A, Hase K, Yamaguchi S, Du D, Sohn BS, Sasaki Y, Yoshida M, Apte RS. LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion. Cell Rep. 2024 May 28;43(5):114102. doi: 10.1016/j.celrep.2024.114102. Copyright 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Recommended Citation

Terao, Ryo; Lee, Tae Jun; Colasanti, Jason; Pfeifer, Charles W; Lin, Joseph B; Santeford, Andrea; Hase, Keitaro; Yamaguchi, Shinobu; Du, Daniel; Sohn, Brian S; Sasaki, Yo; Yoshida, Mitsukuni; and Apte, Rajendra S, "LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion." Cell Reports. 43, 5. 114102 (2024).
https://digitalcommons.wustl.edu/oa_4/4625

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.