Dual orexin receptor antagonism with lemborexant enhances microglial clearance of β-amyloid in mice

Authors

• Ashish Sharma, Washington University School of Medicine in St. Louis
• Emiko Segawa, Eisai Co., Ltd.
• Xiaoying Chen, Tsinghua University
• Sohui Park, Washington University School of Medicine in St. Louis
• Shoutang Wang, Washington University School of Medicine in St. Louis
• Riley E Irmen, University of Kentucky
• Nicholas J Constantino, University of Kentucky
• Chanung Wang, Washington University School of Medicine in St. Louis
• Michael F Kanan, Washington University School of Medicine in St. Louis
• Marco Colonna, Washington University School of Medicine in St. Louis
• Shannon L Macauley, University of Kentucky
• Jocelyn Y Cheng, Eisai Inc.
• Ken Hatanaka, Eisai Co., Ltd.
• Margaret Moline, Eisai Inc.
• Erik S Musiek, Washington University School of Medicine in St. Louis

Journal

Molecular Neurodegeneration

Publication Date

5-22-2026

Volume

21

Issue

1

First Page

28

Document Type

Open Access Publication

DOI

10.1186/s13024-026-00948-y

Rights and Permissions

Sharma, A., Segawa, E., Chen, X. et al. Dual orexin receptor antagonism with lemborexant enhances microglial clearance of β-amyloid in mice. Mol Neurodegeneration 21, 28 (2026). https://doi.org/10.1186/s13024-026-00948-y This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Recommended Citation

Sharma, Ashish; Segawa, Emiko; Chen, Xiaoying; Park, Sohui; Wang, Shoutang; Irmen, Riley E; Constantino, Nicholas J; Wang, Chanung; Kanan, Michael F; Colonna, Marco; Macauley, Shannon L; Cheng, Jocelyn Y; Hatanaka, Ken; Moline, Margaret; and Musiek, Erik S, "Dual orexin receptor antagonism with lemborexant enhances microglial clearance of β-amyloid in mice." Molecular Neurodegeneration. 21, 1. 28 (2026).
https://digitalcommons.wustl.edu/oa_4/7314

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.