Exploring cellular heterogeneity: single-cell and spatial transcriptomics of Alzheimer's disease brains and iPSC-derived microglia

Authors

• Anjali Garg, Washington University School of Medicine in St. Louis
• Sheeny Vo, The Ohio State University
• Iara D De Souza, The Ohio State University
• Ayslan Castro Brant, The Ohio State University
• Logan Brase, Washington University School of Medicine in St. Louis
• Ekaterina Aladyeva, Washington University School of Medicine in St. Louis
• Ricardo D 'o Albanus, Washington University School of Medicine in St. Louis
• Aasritha Nallapu, Washington University School of Medicine in St. Louis
• Hongjun Fu, The Ohio State University
• Oscar Harari, Washington University School of Medicine in St. Louis

Journal

Alzheimer's Research & Therapy

Publication Date

12-28-2025

Volume

18

Issue

1

First Page

22

Document Type

Open Access Publication

DOI

10.1186/s13195-025-01944-y

Rights and Permissions

Garg, A., Vo, S., De Souza, I.D. et al. Exploring cellular heterogeneity: single-cell and spatial transcriptomics of Alzheimer's disease brains and iPSC-derived microglia. Alz Res Therapy 18, 22 (2026). https://doi.org/10.1186/s13195-025-01944-y This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Garg, Anjali; Vo, Sheeny; De Souza, Iara D; Castro Brant, Ayslan; Brase, Logan; Aladyeva, Ekaterina; Albanus, Ricardo D 'o; Nallapu, Aasritha; Fu, Hongjun; and Harari, Oscar, "Exploring cellular heterogeneity: single-cell and spatial transcriptomics of Alzheimer's disease brains and iPSC-derived microglia." Alzheimer's Research & Therapy. 18, 1. 22 (2025).
https://digitalcommons.wustl.edu/oa_4/7365

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.