U2af1S34F and U2af1Q157R myeloid neoplasm-associated hotspot mutations induce distinct hematopoietic phenotypes in mice

Authors

• Michael O Alberti, Washington University School of Medicine in St. Louis
• Sridhar Nonavinkere Srivatsan, Washington University School of Medicine in St. Louis
• Jin Shao, Washington University School of Medicine in St. Louis
• Dennis L Fei, Weill Cornell Medical College
• Mengou Zhu, Washington University School of Medicine in St. Louis
• Claudia Cabrera Pastrana, Washington University School of Medicine in St. Louis
• Monique Chavez, Washington University School of Medicine in St. Louis
• Stefan P Tarnawsky, Washington University School of Medicine in St. Louis
• Sarah Grieb, Washington University School of Medicine in St. Louis
• Timothy A Graubert, Harvard University
• Omar Abdel-Wahab, Memorial Sloan Kettering Cancer Center
• Matthew J Walter, Washington University School of Medicine in St. Louis

Journal

Leukemia

Publication Date

7-1-2026

Volume

40

Issue

7

First Page

1467

Last Page

1481

Document Type

Open Access Publication

DOI

10.1038/s41375-026-02974-7

Rights and Permissions

Alberti, M.O., Nonavinkere Srivatsan, S., Shao, J. et al. U2af1S34F and U2af1Q157R myeloid neoplasm-associated hotspot mutations induce distinct hematopoietic phenotypes in mice. Leukemia 40, 1467–1481 (2026). https://doi.org/10.1038/s41375-026-02974-7 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Recommended Citation

Alberti, Michael O; Nonavinkere Srivatsan, Sridhar; Shao, Jin; Fei, Dennis L; Zhu, Mengou; Pastrana, Claudia Cabrera; Chavez, Monique; Tarnawsky, Stefan P; Grieb, Sarah; Graubert, Timothy A; Abdel-Wahab, Omar; and Walter, Matthew J, "U2af1S34F and U2af1Q157R myeloid neoplasm-associated hotspot mutations induce distinct hematopoietic phenotypes in mice." Leukemia. 40, 7. 1467 - 1481. (2026).
https://digitalcommons.wustl.edu/oa_4/7491

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.