IRS: Iterative reference selection improves normalization of microbiome sequencing data

Authors

• Yiming Shi, Washington University School of Medicine in St. Louis
• Lili Liu, Washington University School of Medicine in St. Louis
• Jun Chen, Mayo Clinic
• Kristine M Wylie, Washington University School of Medicine in St. Louis
• Todd N Wylie, Washington University School of Medicine in St. Louis
• Sung Hee Park, Washington University School of Medicine in St. Louis
• Ruiwen Zhou, Washington University School of Medicine in St. Louis
• Yin Cao, Washington University School of Medicine in St. Louis
• Stephanie A Fritz, Washington University School of Medicine in St. Louis
• Molly J Stout, University of Michigan - Ann Arbor
• Maria Cristina Vazquez Guillamet, Washington University School of Medicine in St. Louis
• Lei Liu, Washington University School of Medicine in St. Louis

Journal

Briefings in bioinformatics

Publication Date

9-1-2026

Volume

27

Issue

5

First Page

bbag495

Document Type

Open Access Publication

DOI

10.1093/bib/bbag495

Rights and Permissions

Yiming Shi, Lili Liu, Jun Chen, Kristine M Wylie, Todd N Wylie, Sung Hee Park, Ruiwen Zhou, Yin Cao, Stephanie A Fritz, Molly J Stout, Maria Cristina Vazquez Guillamet, Lei Liu, IRS: iterative reference selection improves normalization of microbiome sequencing data, Briefings in Bioinformatics, Volume 27, Issue 5, September 2026, bbag495, https://doi.org/10.1093/bib/bbag495. https://academic.oup.com/bib/article/27/5/bbag495/8793670?login=true. © The Author(s) 2026. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected].

Recommended Citation

Shi, Yiming; Liu, Lili; Chen, Jun; Wylie, Kristine M; Wylie, Todd N; Park, Sung Hee; Zhou, Ruiwen; Cao, Yin; Fritz, Stephanie A; Stout, Molly J; Vazquez Guillamet, Maria Cristina; and Liu, Lei, "IRS: Iterative reference selection improves normalization of microbiome sequencing data." Briefings in bioinformatics. 27, 5. bbag495 (2026).
https://digitalcommons.wustl.edu/oa_4/7498

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.