Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Authors

• Shweta Tendulkar, Washington University School of Medicine in St. Louis
• Tong Wu, Washington University School of Medicine in St. Louis
• Amy Strickland, Washington University School of Medicine in St. Louis
• Amber R. Hackett, Washington University School of Medicine in St. Louis
• Yurie Sato-Yamada, Center for Advanced Oral Science
• Xianrong Mao, Washington University School of Medicine in St. Louis
• Yo Sasaki, Washington University School of Medicine in St. Louis
• Jeffrey Milbrandt, Washington University School of Medicine in St. Louis
• A. Joseph Bloom, Washington University School of Medicine in St. Louis
• Aaron DiAntonio, Washington University School of Medicine in St. Louis

Journal

PLoS One

Publication Date

1-1-2026

Volume

21

Issue

4

First Page

e0347135

Document Type

Open Access Publication

DOI

10.1371/journal.pone.0347135

Rights and Permissions

Tendulkar S, Wu T, Strickland A, Hackett AR, Sato-Yamada Y, Mao X, Sasaki Y, Milbrandt J, Bloom AJ, DiAntonio A. Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline. PLoS One. 2026 Apr 17;21(4):e0347135. doi: 10.1371/journal.pone.0347135.© 2026 Tendulkar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Recommended Citation

Tendulkar, Shweta; Wu, Tong; Strickland, Amy; Hackett, Amber R.; Sato-Yamada, Yurie; Mao, Xianrong; Sasaki, Yo; Milbrandt, Jeffrey; Bloom, A. Joseph; and DiAntonio, Aaron, "Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline." PLoS One. 21, 4. e0347135 (2026).
https://digitalcommons.wustl.edu/oa_4/7500

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.