A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms

Authors

• Lohany Diax Mamede, Saint Louis University
• Miwei Hu, Washington University School of Medicine in St. Louis
• Jaime Vaquer-Alicea, University of Texas Southwestern Medical Center
• Amanda R. Titus, Saint Louis University
• Patricia M. Passos, Saint Louis University
• Erica Lantelme, Washington University School of Medicine in St. Louis
• Rachel L French, Agilent Technologies
• Paige A. Kirschner, Washington University School of Medicine in St. Louis
• Marc I. Diamond, University of Texas Southwestern Medical Center
• Timothy M. Miller, Washington University School of Medicine in St. Louis
• Yuna M. Ayala, Saint Louis University

Journal

PLoS Biology

Publication Date

3-1-2026

Volume

24

Issue

3

First Page

e3003662

Document Type

Open Access Publication

DOI

10.1371/journal.pbio.3003662

Rights and Permissions

Mamede LD, Hu M, Vaquer-Alicea J, Titus AR, Passos PM, Lantelme E, French RL, Kirschner PA, Diamond MI, Miller TM, Ayala YM. A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms. PLoS Biol. 2026 Mar 24;24(3):e3003662. doi: 10.1371/journal.pbio.3003662. © 2026 Mamede et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Recommended Citation

Mamede, Lohany Diax; Hu, Miwei; Vaquer-Alicea, Jaime; Titus, Amanda R.; Passos, Patricia M.; Lantelme, Erica; French, Rachel L; Kirschner, Paige A.; Diamond, Marc I.; Miller, Timothy M.; and Ayala, Yuna M., "A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms." PLoS Biology. 24, 3. e3003662 (2026).
https://digitalcommons.wustl.edu/oa_4/7503

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.