Modular in vivo antibody-ADC click to reverse drug resistance in tumours

Authors

• Cristina Simó, Washington University School of Medicine in St. Louis
• Alexander C Vanover, Washington University School of Medicine in St. Louis
• Ricardo D'Oliveira Albanus, Washington University School of Medicine in St. Louis
• Sandeep Surendra Panikar, Washington University School of Medicine in St. Louis
• Shayla Shmuel, Washington University School of Medicine in St. Louis
• Alex Benton, Washington University School of Medicine in St. Louis
• Jader Giraldo-Guzman, Washington University School of Medicine in St. Louis
• José M Luna, Washington University School of Medicine in St. Louis
• Yifei Xu, Washington University School of Medicine in St. Louis
• Na-Keysha Berry, Washington University School of Medicine in St. Louis
• Nai Keltee, Washington University School of Medicine in St. Louis
• Jingxia Liu, Washington University School of Medicine in St. Louis
• Farrokh Dehdashti, Washington University School of Medicine in St. Louis
• Patrícia M R Pereira, Washington University School of Medicine in St. Louis

Journal

Nature

Publication Date

9-1-2026

Volume

657

Issue

8130

First Page

252

Last Page

261

Document Type

Open Access Publication

DOI

10.1038/s41586-026-10789-w

Rights and Permissions

Simó, C., Vanover, A.C., D’Oliveira Albanus, R. et al. Modular in vivo antibody–ADC click to reverse drug resistance in tumours. Nature 657, 252–261 (2026). https://doi.org/10.1038/s41586-026-10789-w This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Simó, Cristina; Vanover, Alexander C; D'Oliveira Albanus, Ricardo; Panikar, Sandeep Surendra; Shmuel, Shayla; Benton, Alex; Giraldo-Guzman, Jader; Luna, José M; Xu, Yifei; Berry, Na-Keysha; Keltee, Nai; Liu, Jingxia; Dehdashti, Farrokh; and Pereira, Patrícia M R, "Modular in vivo antibody-ADC click to reverse drug resistance in tumours." Nature. 657, 8130. 252 - 261. (2026).
https://digitalcommons.wustl.edu/oa_4/7520

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.