Biological aging and generational shifts in early-onset cancer risk

Authors

• Ruiyi Tian, Washington University School of Medicine in St. Louis
• Xiaoyu Zong, Washington University School of Medicine in St. Louis
• Duo Ren, Washington University School of Medicine in St. Louis
• Stefani Tica, Washington University School of Medicine in St. Louis
• Daniel Hong, Washington University School of Medicine in St. Louis
• Oluseye Oduyale, Washington University School of Medicine in St. Louis
• Jason D Buenrostro, Harvard University
• Ramaswamy Govindan, Washington University School of Medicine in St. Louis
• Yin Cao, Washington University School of Medicine in St. Louis

Journal

Nature Medicine

Publication Date

8-1-2026

Volume

32

Issue

8

First Page

2983

Last Page

2990

Document Type

Open Access Publication

DOI

10.1038/s41591-026-04448-w

Rights and Permissions

Tian, R., Zong, X., Ren, D. et al. Biological aging and generational shifts in early-onset cancer risk. Nat Med 32, 2983–2990 (2026). https://doi.org/10.1038/s41591-026-04448-w This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Recommended Citation

Tian, Ruiyi; Zong, Xiaoyu; Ren, Duo; Tica, Stefani; Hong, Daniel; Oduyale, Oluseye; Buenrostro, Jason D; Govindan, Ramaswamy; and Cao, Yin, "Biological aging and generational shifts in early-onset cancer risk." Nature Medicine. 32, 8. 2983 - 2990. (2026).
https://digitalcommons.wustl.edu/oa_4/7570

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.