Cardiac radiotherapy-induced epigenetic memory underlies electrophysiologic and metabolic reprogramming

Authors

• Samuel D. Jordan, Washington University School of Medicine in St. Louis
• Shuhua Fu, Washington University School of Medicine in St. Louis
• Abigail Fulkerson, Washington University School of Medicine in St. Louis
• Donghua Hu, Washington University School of Medicine in St. Louis
• Sherwin Ng, Washington University School of Medicine in St. Louis
• David M. Zhang, Washington University School of Medicine in St. Louis
• Sneha Manikandan, Washington University School of Medicine in St. Louis
• Jeffrey Szymanski, Washington University School of Medicine in St. Louis
• Nan Hu, Washington University School of Medicine in St. Louis
• Yuqian Xie, Washington University School of Medicine in St. Louis
• Anish Bedi, Washington University School of Medicine in St. Louis
• James Tabor, Washington University School of Medicine in St. Louis
• Lauren Boggs-Bailey, Washington University School of Medicine in St. Louis
• Lori Strong, Washington University School of Medicine in St. Louis
• Stephanie Hicks, Washington University School of Medicine in St. Louis
• Lavanya Aryan, Washington University in St. Louis
• Nishanth Gabriel, Washington University School of Medicine in St. Louis
• Geoffrey D. Hugo, Washington University School of Medicine in St. Louis
• Kuo-Chan Weng, Washington University School of Medicine in St. Louis
• Nathaniel Huebsch, Washington University School of Medicine in St. Louis
• Julie K. Schwarz, Washington University School of Medicine in St. Louis
• Bo Zhang, Washington University School of Medicine in St. Louis
• Stacey L. Rentschler, Washington University School of Medicine in St. Louis

Journal

Journal of Clinical Investigation

Publication Date

4-1-2026

Volume

136

Issue

7

First Page

e193087

Document Type

Open Access Publication

DOI

10.1172/JCI193087

Rights and Permissions

Jordan SD, Fu S, Fulkerson A, Hu D, Ng S, Zhang DM, Manikandan S, Szymanski J, Hu N, Xie Y, Bedi A, Tabor J, Boggs-Bailey L, Strong L, Hicks S, Aryan L, Gabriel N, Hugo GD, Weng KC, Huebsch N, Schwarz JK, Zhang B, Rentschler SL. Cardiac radiotherapy-induced epigenetic memory underlies electrophysiologic and metabolic reprogramming. J Clin Invest. 2026 Feb 17;136(7):e193087. doi: 10.1172/JCI193087. © 2026, Jordan et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License

Recommended Citation

Jordan, Samuel D.; Fu, Shuhua; Fulkerson, Abigail; Hu, Donghua; Ng, Sherwin; Zhang, David M.; Manikandan, Sneha; Szymanski, Jeffrey; Hu, Nan; Xie, Yuqian; Bedi, Anish; Tabor, James; Boggs-Bailey, Lauren; Strong, Lori; Hicks, Stephanie; Aryan, Lavanya; Gabriel, Nishanth; Hugo, Geoffrey D.; Weng, Kuo-Chan; Huebsch, Nathaniel; Schwarz, Julie K.; Zhang, Bo; and Rentschler, Stacey L., "Cardiac radiotherapy-induced epigenetic memory underlies electrophysiologic and metabolic reprogramming." Journal of Clinical Investigation. 136, 7. e193087 (2026).
https://digitalcommons.wustl.edu/oa_4/7707

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.