Title

A randomized, open-label study of the tolerability and efficacy of one or three daily doses of ivermectin plus diethylcarbamazine and albendazole (IDA) versus one dose of ivermectin plus albendazole (IA) for treatment of onchocerciasis

Author(s)

Gary J. Weil, Washington University School of Medicine in St. Louis
Peter U. Fischer, Washington University School of Medicine in St. Louis
Nicholas O. Opoku, University of Ghana
Felix Doe, Hohoe Municipal Hospital
Nicole Fetcho, Washington University School of Medicine in St. Louis
Bettina Dubben, University Hospital Bonn
Kerstin Fischer, Washington University School of Medicine in St. Louis
Shelter Gordor, University of Health and Allied Sciences (Ghana)
Charles W. Goss, Washington University School of Medicine in St. Louis
Michael Ekuoba-Gyasi, St. Thomas Eye Hospital (Ghana)
Achim Hoerauf, University Hospital Bonn
Augustine R. Hong, Washington University School of Medicine in St. Louis
Eric Kanza, Universite Catholique du Graben (DRC)
Christopher L. King, Case Western Reserve University
Rukaya Laryea, University of Health and Allied Sciences (Ghana)
Daphne Lew, Washington University School of Medicine in St. Louis
Mahama Seidu Alhassan, University of Ghana

Orcid ID

Gary Weil (0000-0002-6336-3824) (orcid.org) corresponding author

Peter Fischer (0000-0003-4558-3417) (orcid.org) corresponding author

Nicholas Opoku (0000-0001-9495-8874) (orcid.org)

Charles Goss (0000-0003-2682-7316) (orcid.org)

Michael E. Gyasi (0000-0002-6929-2588) (orcid.org)

Achim Hoerauf (0000-0002-8671-3831) (orcid.org)

Augustine Hong (0000-0003-0811-9084) (orcid.org)

Christopher King (0000-0003-3873-7860) (orcid.org)

Rukaya Laryea (0000-0001-9147-118X) (orcid.org)

Daphne Lew (0000-0001-5433-2367) (orcid.org)

MAHAMA SEIDU ALHASSAN (0000-0003-2105-5169) (orcid.org)

Resource Type

Dataset

DOI

https://doi.org/10.48765/xq0p-e188

Funding

Bill and Melinda Gates Foundation [OPP1190749, https://www.gatesfoundation.org]

Description

Data collected from participants at during a clinical trial in Hohoe, Ghana where participants are identified by a unique participant ID. There are two datasets. The Safety dataset includes demographics, skin snip results, adverse event results, and ophthalmological data from baseline, day of treatment, Day 1-7, Month 3, Month 12, and Month 18. The Nodulectomy data set contains data pertaining to sectioned nodules read by scientists at 18 months which indicate embryogenesis in female worms, number of male and female worms, and worm calcification.

Keywords

Communicable Disease, Tropical Medicine, Onchocerciasis, Onchocerca volvulus, Microfilariae, Helminths, Nematoda, Filaricides, Ivermectin, Albendazole, Diethylcarbamazine, Clinical Trial, Ophthalmology, Eye Diseases, Western Africa, Ghana

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Date

5-12-2023

Recommended Citation

Weil, Gary J.; Fischer, Peter U.; Opoku, Nicholas O.; Doe, Felix; Fetcho, Nicole; Dubben, Bettina; Fischer, Kerstin; Gordor, Shelter; Goss, Charles W.; Ekuoba-Gyasi, Michael; Hoerauf, Achim; Hong, Augustine R.; Kanza, Eric; King, Christopher L.; Laryea, Rukaya; Lew, Daphne; and Alhassan, Mahama Seidu, "A randomized, open-label study of the tolerability and efficacy of one or three daily doses of ivermectin plus diethylcarbamazine and albendazole (IDA) versus one dose of ivermectin plus albendazole (IA) for treatment of onchocerciasis" (2023). Data and Supporting Files. Paper 7.
https://digitalcommons.wustl.edu/data/7