Mutational analysis of anesthetic binding sites and their effects on GABAA receptor activation and modulation by positive allosteric modulators of the α7 nicotinic receptor

Spencer R Pierce, Washington University School of Medicine in St. Louis
Allison L Germann, Washington University School of Medicine in St. Louis
Sophia Q Xu, Washington University School of Medicine in St. Louis
Saumith L Menon, Washington University School of Medicine in St. Louis
Marcelo O Ortells, Universidad de Morón
Hugo R Arias, Oklahoma State University
Gustav Akk, Washington University School of Medicine in St. Louis

Abstract

The positive allosteric modulators (PAMs) of the α7 nicotinic receptor