Parent-of-origin effects propagate through networks to shape metabolic traits

Juan F Macias-Velasco, Washington University School of Medicine in St. Louis
Celine L St Pierre, Washington University School of Medicine in St. Louis
Jessica P Wayhart, Washington University School of Medicine in St. Louis
Li Yin, Washington University School of Medicine in St. Louis
Larry Spears, Washington University School of Medicine in St. Louis
Mario A Miranda, Washington University School of Medicine in St. Louis
Caryn Carson, Washington University School of Medicine in St. Louis
Katsuhiko Funai, University of Utah
James M Cheverud, Loyola University
Clay F Semenkovich, Washington University School of Medicine in St. Louis
Heather A Lawson, Washington University School of Medicine in St. Louis

Abstract

Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and neurological traits. Parent-of-origin effects can be modified by the environment, but the architecture of these gene-by-environmental effects on phenotypes remains to be unraveled. Previously, quantitative trait loci (QTL) showing context-specific parent-of-origin effects on metabolic traits were mapped in the F