Molecular characterization of sterol C4-methyl oxidase in Leishmania major

Yu Ning, Texas Tech University
Somrita Basu, Texas Tech University
Fong-Fu Hsu, Washington University School of Medicine in St. Louis
Mei Feng, University of Kansas
Michael Zhuo Wang, University of Kansas
Kai Zhang, Texas Tech University

Abstract

Sterol biosynthesis requires the oxidative removal of two methyl groups from the C-4 position by sterol C-4-demethylase and one methyl group from the C-14 position by sterol C-14-demethylase. In