Journal
Elife
Publication Date
2-2-2021
Volume
10
First Page
e64370
Document Type
Open Access Publication
DOI
10.7554/eLife.64370
Rights and Permissions
eLife 2021;10:e64370 DOI: 10.7554/eLife.64370. © 2021, Fazio et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Fazio, Maurizio; Kaufman, Charles K.; and et al, "SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance." Elife. 10, e64370 (2021).
https://digitalcommons.wustl.edu/open_access_pubs/10132
Figures and figure supplements.pdf (10570 kB)
elife-64370-fig1-data1-v2.xlsx (115 kB)
Kaplan-Meier melanoma-free survival curves input files in weeks showing (1 = tumor, 0 = no tumor/censored, no value = lost at follow up).
elife-64370-supp1-v2.xlsx (32 kB)
Schematic of screened pools of epigenetic factors and source plasmid references.
elife-64370-supp2-v2.xlsx (15787 kB)
Differential gene expression list of primary MCR:SATB2 vs MCR:EGFP tumors by RNA-seq (Sheet 1).
elife-64370-supp3-v2.xlsx (143 kB)
SATB2-associated genes that are neural crest related (Sheet 1) SATB2-associated genes, determined by using GREAT genomic region association ‘Basal plus extension’ (proximal 10 kb upstream of TSS, 5 kb downstream of TSS, distal up to 100 kb).
elife-64370-supp4-v2.xlsx (3440 kB)
RNA-seq of SKMEL2 TetOn SATB2 48 hr +/- doxycycline.
elife-64370-supp5-v2.xlsx (57 kB)
qRT-PCR primers.
elife-64370-video1.mp4 (3980 kB)
Zebrafish MCR:EGFP (unpigmented) and MCR:SATB2 (pigmented) melanoma phenotype.
elife-64370-video2.mp4 (768 kB)
Time-lapse video recording of Oregon Green 488-labeled gelatin degradation upon SATB2 induction in human melanoma cell line A375.
elife-64370-video3.mp4 (1442 kB)
MCR control primary tumor transplant into transparent Casper zebrafish, 3.5 weeks post-transplant.
elife-64370-video4.mp4 (1656 kB)
MCR:SATB2 primary tumor transplant into transparent Casper zebrafish, 3.5 weeks post-transplant.
elife-64370-transrepform-v2.docx (250 kB)
elife-64370-fig1-data1-v2.xlsx (115 kB)
Kaplan-Meier melanoma-free survival curves input files in weeks showing (1 = tumor, 0 = no tumor/censored, no value = lost at follow up).
elife-64370-supp1-v2.xlsx (32 kB)
Schematic of screened pools of epigenetic factors and source plasmid references.
elife-64370-supp2-v2.xlsx (15787 kB)
Differential gene expression list of primary MCR:SATB2 vs MCR:EGFP tumors by RNA-seq (Sheet 1).
elife-64370-supp3-v2.xlsx (143 kB)
SATB2-associated genes that are neural crest related (Sheet 1) SATB2-associated genes, determined by using GREAT genomic region association ‘Basal plus extension’ (proximal 10 kb upstream of TSS, 5 kb downstream of TSS, distal up to 100 kb).
elife-64370-supp4-v2.xlsx (3440 kB)
RNA-seq of SKMEL2 TetOn SATB2 48 hr +/- doxycycline.
elife-64370-supp5-v2.xlsx (57 kB)
qRT-PCR primers.
elife-64370-video1.mp4 (3980 kB)
Zebrafish MCR:EGFP (unpigmented) and MCR:SATB2 (pigmented) melanoma phenotype.
elife-64370-video2.mp4 (768 kB)
Time-lapse video recording of Oregon Green 488-labeled gelatin degradation upon SATB2 induction in human melanoma cell line A375.
elife-64370-video3.mp4 (1442 kB)
MCR control primary tumor transplant into transparent Casper zebrafish, 3.5 weeks post-transplant.
elife-64370-video4.mp4 (1656 kB)
MCR:SATB2 primary tumor transplant into transparent Casper zebrafish, 3.5 weeks post-transplant.
elife-64370-transrepform-v2.docx (250 kB)
