Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis

Authors

Whasil Lee, Duke University
Robert J. Nims, Washington University School of Medicine in St. Louis
Alireza Savadipour, Washington University School of Medicine in St. Louis
Qiaojuan Zhang, Duke University
Holly A. Leddy, Duke University
Fang Liu, Duke University
Amy L. McNulty, Duke University
Yong Chen, Duke University
Farshid Guilak, Washington University School of Medicine in St. Louis
Wolfgang B. Liedtke, Duke University

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Date

2021

Volume

118

Issue

13

First Page

e2001611118

Document Type

Open Access Publication

DOI

10.1073/pnas.2001611118

Rights and Permissions

Lee, W., Nims, R. J., Savadipour, A., Zhang, Q., Leddy, H. A., Liu, F., . . . Liedtke, W. B. (2021). Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America, 118(13) doi:10.1073/pnas.2001611118 Copyright © 2021 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Recommended Citation

Lee, Whasil; Nims, Robert J.; Savadipour, Alireza; Zhang, Qiaojuan; Leddy, Holly A.; Liu, Fang; McNulty, Amy L.; Chen, Yong; Guilak, Farshid; and Liedtke, Wolfgang B., "Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis." Proceedings of the National Academy of Sciences of the United States of America. 118, 13. e2001611118 (2021).
https://digitalcommons.wustl.edu/open_access_pubs/10214