Journal
Elife
Publication Date
5-28-2021
Volume
10
First Page
e65762
Document Type
Open Access Publication
DOI
10.7554/eLife.65762
Rights and Permissions
eLife 2021;10:e65762 DOI: 10.7554/eLife.65762. © 2021, Lebratti et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Lebratti, Tania; Lim, Ying Shiang; Cofie, Adjoa; Andhey, Prabhakar; Jiang, Xiaoping; Scott, Jason; Fabbrizi, Maria Rita; Ozantürk, Ayşe Naz; Pham, Christine; Clemens, Regina; Artyomov, Maxim; Dinauer, Mary; and Shin, Haina, "A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection." Elife. 10, e65762 (2021).
https://digitalcommons.wustl.edu/open_access_pubs/10428
elife-65762-fig1-data1-v1.xlsx (13 kB)
Figure 1—source data 1. Excel file with individual inflammation scores, viral titers, tissue weights, description of statistical tests, epsilon values and actual p values for Figure 1.
elife-65762-fig1-data2-v1.xlsx (19 kB)
Figure 1—source data 2. Excel file with individual cell numbers and frequencies, inflammation scores, viral titers, description of statistical tests, epsilon values and actual p values for Figure 1—figure supplements 1–4.
elife-65762-fig2-data1-v1.xlsx (10 kB)
Figure 2—source data 1. Excel file with individual inflammation scores, cell numbers, description of statistical tests, epsilon values and actual p values for Figure 2.
elife-65762-fig3-data1-v1.xlsx (3030 kB)
Figure 3—source data 1. Excel file with individual ELISA measurements, lists of differentially expressed genes between different neutrophil clusters, description of statistical tests and actual p values for Figure 3.
elife-65762-fig3-data2-v1.xlsx (1280 kB)
Figure 3—source data 2. Excel file with lists of differentially expressed genes between neutrophils between HSV-1 and HSV-2 infected mice, individual delta Cq values, ELISA measurements, description of statistical tests and actual p values for Figure 3—figure supplements 1–3.
elife-65762-fig4-data1-v1.xlsx (10 kB)
Figure 4—source data 1. Excel file with indiviual inflammation scores, viral titers, description of statistical tests, epsilon values and actual p values for Figure 4.
elife-65762-fig5-data1-v1.xlsx (10 kB)
Figure 5—source data 1. Excel file with individual cell numbers, inflammation scores, viral titers, description of statistical tests, epsilon values and actual p values for Figure 5.
elife-65762-fig6-data1-v1.xlsx (11 kB)
Figure 6—source data 1. Excel file with individual ELISA measurements, inflammation scores, viral titers, description of statistical tests, epsilon values and actual p values for Figure 6.
Figures and figure supplements.pdf (4065 kB)
Transparent reporting form.doc (265 kB)
Author Response Image.jpg (11 kB)
Mice depleted of neutrophils have a higher survival rate compared to controls.
Figure 1—source data 1. Excel file with individual inflammation scores, viral titers, tissue weights, description of statistical tests, epsilon values and actual p values for Figure 1.
elife-65762-fig1-data2-v1.xlsx (19 kB)
Figure 1—source data 2. Excel file with individual cell numbers and frequencies, inflammation scores, viral titers, description of statistical tests, epsilon values and actual p values for Figure 1—figure supplements 1–4.
elife-65762-fig2-data1-v1.xlsx (10 kB)
Figure 2—source data 1. Excel file with individual inflammation scores, cell numbers, description of statistical tests, epsilon values and actual p values for Figure 2.
elife-65762-fig3-data1-v1.xlsx (3030 kB)
Figure 3—source data 1. Excel file with individual ELISA measurements, lists of differentially expressed genes between different neutrophil clusters, description of statistical tests and actual p values for Figure 3.
elife-65762-fig3-data2-v1.xlsx (1280 kB)
Figure 3—source data 2. Excel file with lists of differentially expressed genes between neutrophils between HSV-1 and HSV-2 infected mice, individual delta Cq values, ELISA measurements, description of statistical tests and actual p values for Figure 3—figure supplements 1–3.
elife-65762-fig4-data1-v1.xlsx (10 kB)
Figure 4—source data 1. Excel file with indiviual inflammation scores, viral titers, description of statistical tests, epsilon values and actual p values for Figure 4.
elife-65762-fig5-data1-v1.xlsx (10 kB)
Figure 5—source data 1. Excel file with individual cell numbers, inflammation scores, viral titers, description of statistical tests, epsilon values and actual p values for Figure 5.
elife-65762-fig6-data1-v1.xlsx (11 kB)
Figure 6—source data 1. Excel file with individual ELISA measurements, inflammation scores, viral titers, description of statistical tests, epsilon values and actual p values for Figure 6.
Figures and figure supplements.pdf (4065 kB)
Transparent reporting form.doc (265 kB)
Author Response Image.jpg (11 kB)
Mice depleted of neutrophils have a higher survival rate compared to controls.
