Journal
Elife
Publication Date
2021
Volume
10
First Page
e68864
Document Type
Open Access Publication
DOI
10.7554/eLife.68864
Rights and Permissions
eLife 2021;10:e68864 DOI: 10.7554/eLife.68864. © 2021, Myers et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Myers, Margaret A.; Smith, Amanda P.; Lane, Lindey C.; Moquin, David J.; Aogo, Rosemary; Woolard, Stacie; Thomas, Paul; Vogel, Peter; and Smith, Amber M., "Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity." Elife. 10, e68864 (2021).
https://digitalcommons.wustl.edu/open_access_pubs/10831
Source Code 1.zip (168 kB)
Source code files for reproduction of all figures.
Source Data 1.xlsx (16 kB)
Source data including viral titers, CD8+ T cells, inflammation, lesion, and weight loss.
Supplementary File 1.pdf (50 kB)
Statistical comparison of alternate models. Comparison of the Akaike Information Criteria (AIC) of the CD8+ T cell model in Equation (1)-(6), the alternate model in Equation (A1)-(A6), and the Baral model in Equation (A7)-(A8). The fit of these models is shown in Appendix 1—figure 1.
Supplementary File 2.pdf (72 kB)
CD8 T cell depletion model parameters. Parameters, SSR, and AICC obtained from fitting the CD8+ T cell model (Equation (1)-(6)) to viral titers and CD8+ T cells from mice infected with 75 TCID50 PR8 and with CD8+ T cells depleted at −2 d, 0 d, 3 d, and 7 d pi. The total number of CD8+ T cells is E^=E+EM+E0^, where E0^=5.6×103 cells, and all other parameters are those in Table 1. The best model is bolded.
Transparent Reporting Form.docx (111 kB)
Source code files for reproduction of all figures.
Source Data 1.xlsx (16 kB)
Source data including viral titers, CD8+ T cells, inflammation, lesion, and weight loss.
Supplementary File 1.pdf (50 kB)
Statistical comparison of alternate models. Comparison of the Akaike Information Criteria (AIC) of the CD8+ T cell model in Equation (1)-(6), the alternate model in Equation (A1)-(A6), and the Baral model in Equation (A7)-(A8). The fit of these models is shown in Appendix 1—figure 1.
Supplementary File 2.pdf (72 kB)
CD8 T cell depletion model parameters. Parameters, SSR, and AICC obtained from fitting the CD8+ T cell model (Equation (1)-(6)) to viral titers and CD8+ T cells from mice infected with 75 TCID50 PR8 and with CD8+ T cells depleted at −2 d, 0 d, 3 d, and 7 d pi. The total number of CD8+ T cells is E^=E+EM+E0^, where E0^=5.6×103 cells, and all other parameters are those in Table 1. The best model is bolded.
Transparent Reporting Form.docx (111 kB)
