Journal
Elife
Publication Date
2021
Volume
10
First Page
e69264
Document Type
Open Access Publication
DOI
10.7554/eLife.69264
Rights and Permissions
eLife 2021;10:e69264 DOI: 10.7554/eLife.69264. © 2021, Holmgren et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Holmgren, Melanie; Ravicz, Michael E.; Hancock, Kenneth E.; Strelkova, Olga; Kallogjeri, Dorina; Indzhykulian, Artur A.; Warchol, Mark E.; and Sheets, Lavinia, "Mechanical overstimulation causes acute injury and synapse loss followed by fast recovery in lateral-line neuromasts of larval zebrafish." Elife. 10, e69264 (2021).
https://digitalcommons.wustl.edu/open_access_pubs/10968
elife-69264-fig2-data1-v2.xlsx (20 kB)
Figure 2—source data 1 Summary of normal and disrupted neuromast counts following sustained and periodic stimulus exposures.
elife-69264-fig2-data2-v2.xlsx (14 kB)
Figure 2—source data 2 ummary of normal and disrupted neuromast counts in lhfpl5b mutants and wildtype siblings following sustained stimulus exposure.
elife-69264-fig3-data1-v2.xlsx (55 kB)
Figure 3—source data 1 Raw data and statistical analysis of hair-cell counts and innervation immediately following sustained stimulus exposure.
elife-69264-fig4-data1-v2.xlsx (51 kB)
Figure 4—source data 1 Raw data and statistical analysis of synapse counts immediately following sustained stimulus exposure.
elife-69264-fig7-data1-v2.xlsx (18 kB)
Figure 7—source data 1 Summary of normal and disrupted neuromast counts following sustained exposure with 0, 2, or 48 hr recovery.
elife-69264-fig7-data2-v2.xlsx (33 kB)
Figure 7—source data 2 Raw data and statistical analysis of hair-cell counts and innervation following sustained stimulus exposure with 0 and 2 hr recovery.
elife-69264-fig7-data3-v2.xlsx (29 kB)
Figure 7—source data 3 Raw data and statistical analysis of hair-cell counts and innervation following sustained stimulus exposure with 0 and 48 hr recovery.
elife-69264-video1.mp4 (4328 kB)
Swimming behavior of control fish with intact lateral line organs. Magenta circle indicates a fish prior to a ‘fast escape’ response.
elife-69264-video2.mp4 (4045 kB)
Swimming behavior of larvae whose lateral-line neuromasts were ablated with CuSO4. Magenta circles indicate larvae that were swept into the waves and could no longer tracked.
Figures and figure supplements.pdf (15641 kB)
elife-69264-transrepform1-v2.pdf (152 kB)
Transparent reporting form
Figure 2—source data 1 Summary of normal and disrupted neuromast counts following sustained and periodic stimulus exposures.
elife-69264-fig2-data2-v2.xlsx (14 kB)
Figure 2—source data 2 ummary of normal and disrupted neuromast counts in lhfpl5b mutants and wildtype siblings following sustained stimulus exposure.
elife-69264-fig3-data1-v2.xlsx (55 kB)
Figure 3—source data 1 Raw data and statistical analysis of hair-cell counts and innervation immediately following sustained stimulus exposure.
elife-69264-fig4-data1-v2.xlsx (51 kB)
Figure 4—source data 1 Raw data and statistical analysis of synapse counts immediately following sustained stimulus exposure.
elife-69264-fig7-data1-v2.xlsx (18 kB)
Figure 7—source data 1 Summary of normal and disrupted neuromast counts following sustained exposure with 0, 2, or 48 hr recovery.
elife-69264-fig7-data2-v2.xlsx (33 kB)
Figure 7—source data 2 Raw data and statistical analysis of hair-cell counts and innervation following sustained stimulus exposure with 0 and 2 hr recovery.
elife-69264-fig7-data3-v2.xlsx (29 kB)
Figure 7—source data 3 Raw data and statistical analysis of hair-cell counts and innervation following sustained stimulus exposure with 0 and 48 hr recovery.
elife-69264-video1.mp4 (4328 kB)
Swimming behavior of control fish with intact lateral line organs. Magenta circle indicates a fish prior to a ‘fast escape’ response.
elife-69264-video2.mp4 (4045 kB)
Swimming behavior of larvae whose lateral-line neuromasts were ablated with CuSO4. Magenta circles indicate larvae that were swept into the waves and could no longer tracked.
Figures and figure supplements.pdf (15641 kB)
elife-69264-transrepform1-v2.pdf (152 kB)
Transparent reporting form
