Opening of a cryptic pocket in β-lactamase increases penicillinase activity

Authors

Catherine R Knoverek, Washington University School of Medicine in St. Louis
Upasana L Mallimadugula, Washington University School of Medicine in St. Louis
Sukrit Singh, Washington University School of Medicine in St. Louis
Enrico Rennella, University of Toronto
Thomas E Frederick, Washington University School of Medicine in St. Louis
Tairan Yuwen, Peking University
Shreya Raavicharla, Washington University School of Medicine in St. Louis
Lewis E Kay, University of Toronto
Gregory R Bowman, Washington University School of Medicine in St. Louis

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Date

11-23-2021

Volume

118

Issue

47

First Page

e2106473118

Document Type

Open Access Publication

DOI

10.1073/pnas.2106473118

Rights and Permissions

Catherine R. Knoverek, Upasana L. Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E. Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E. Kay, Gregory R. Bowman (2021) Opening of a cryptic pocket in β-lactamase increases penicillinase activity. Proceedings of the National Academy of Sciences, 118 (47): e2106473118. DOI: 10.1073/pnas.2106473118. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Recommended Citation

Knoverek, Catherine R; Mallimadugula, Upasana L; Singh, Sukrit; Rennella, Enrico; Frederick, Thomas E; Yuwen, Tairan; Raavicharla, Shreya; Kay, Lewis E; and Bowman, Gregory R, "Opening of a cryptic pocket in β-lactamase increases penicillinase activity." Proceedings of the National Academy of Sciences of the United States of America. 118, 47. e2106473118 (2021).
https://digitalcommons.wustl.edu/open_access_pubs/11019