Journal
Elife
Publication Date
2021
Volume
10
First Page
e71689
Document Type
Open Access Publication
DOI
10.7554/eLife.71689
Rights and Permissions
eLife 2021;10:e71689 DOI: 10.7554/eLife.71689. © 2021, Meng et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Meng, Qing-Tao; Liu, Xian-Yu; Liu, Xue-Ting; Liu, Juan; Munanairi, Admire; Barry, Devin M.; Liu, Benlong; Jin, Hua; Sun, Yu; Yang, Qianyi; Gao, Fang; Wan, Li; Peng, Jiahang; Jin, Jin-Hua; Shen, Kai-Feng; Kim, Ray; Yin, Jun; Tao, Ailin; and Chen, Zhou-Feng, "BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk." Elife. 10, e71689 (2021).
https://digitalcommons.wustl.edu/open_access_pubs/11213
elife-71689-fig1-data1-v2.xlsx (11 kB)
Figure 1—source data 1 BNP dose-dependently evoked scratching behaviors and showed a delayed onset of scratching responses.
elife-71689-fig2-data1-v2.xlsx (12 kB)
Figure 2—source data 1 NPRA and NPRC are involved in acute itch.
elife-71689-fig3-data1-v2.xlsx (11 kB)
Figure 3—source data 1 BNP facilitates histamine itch.
elife-71689-fig4-data1-v2.xlsx (9 kB)
Figure 4—source data 1 Potentiation of NMB-evoked calcium and scratching responses by BNP requires Gi-Gq crosstalk between NPRC-NMBR.
elife-71689-fig5-data1-v2.xlsx (10 kB)
Figure 5—source data 1 BNP-sap ablates spinal cord neurons expressing Npr1 and Npr3.
elife-71689-fig6-data1-v2.xlsx (10 kB)
Figure 6—source data 1 SST evoked both pain and itch responses in mice.
Transparent reporting form.docx (244 kB)