Journal
Elife
Publication Date
2022
Volume
11
First Page
e72801
Document Type
Open Access Publication
DOI
10.7554/eLife.72801
Rights and Permissions
eLife 2022;11:e72801 DOI: 10.7554/eLife.72801. © 2022, Fishbein et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Fishbein, Skye R.S.; Robinson, John I.; Hink, Tiffany; Reske, Kimberly A.; Newcomer, Erin P.; Burnham, Carey-Ann D.; Henderson, Jeffrey P.; Dubberke, Erik R.; and Dantas, Gautam, "Multi-omics investigation of Clostridioides difficile-colonized patients reveals pathogen and commensal correlates of C. difficile pathogenesis." Elife. 11, e72801 (2022).
https://digitalcommons.wustl.edu/open_access_pubs/11249
elife-72801-fig1-data1-v1.xlsx (14 kB)
Figure 1—source data 1 Raw absorbance value for in vitro toxin ELISA of 102 C.difficile isolates.
elife-72801-fig3-data1-v1.xlsx (101 kB)
Figure 3—source data 1 Growth curve data for C. difficile isolates.
elife-72801-sa2-fig1-v1.jpg (49 kB)
Maaslin2 analysis of metagenomes with C. difficile reads removed and compositional dataset renormalized.
elife-72801-sa2-fig2-v1.jpg (52 kB)
Maaslin2 analysis of stool metagenomes with detectable C. difficile.</Author response image 2 title/legend>.
elife-72801-sa2-fig3-v1.jpg (56 kB)
elife-72801-supp1-v1.xlsx (9 kB)
Supplementary file 1 Patient demographic data.
elife-72801-supp2-v1.xlsx (12 kB)
Supplementary file 2 Fecal metagenomics metadata file with isolate information.
elife-72801-supp3-v1.xlsx (18 kB)
Supplementary file 3 MaAsLin2 output of metabolites associated with EIA status in addition to metabolite validation information.
elife-72801-supp4-v1.xlsx (714 kB)
Supplementary file 4 DEseq output of in vitro rhamnose-exposed C difficile transcriptomic profiling.
elife-72801-transrepform1-v1.pdf (336 kB)
Transparent reporting form
Figure 1—source data 1 Raw absorbance value for in vitro toxin ELISA of 102 C.difficile isolates.
elife-72801-fig3-data1-v1.xlsx (101 kB)
Figure 3—source data 1 Growth curve data for C. difficile isolates.
elife-72801-sa2-fig1-v1.jpg (49 kB)
Maaslin2 analysis of metagenomes with C. difficile reads removed and compositional dataset renormalized.
elife-72801-sa2-fig2-v1.jpg (52 kB)
Maaslin2 analysis of stool metagenomes with detectable C. difficile.</Author response image 2 title/legend>.
elife-72801-sa2-fig3-v1.jpg (56 kB)
elife-72801-supp1-v1.xlsx (9 kB)
Supplementary file 1 Patient demographic data.
elife-72801-supp2-v1.xlsx (12 kB)
Supplementary file 2 Fecal metagenomics metadata file with isolate information.
elife-72801-supp3-v1.xlsx (18 kB)
Supplementary file 3 MaAsLin2 output of metabolites associated with EIA status in addition to metabolite validation information.
elife-72801-supp4-v1.xlsx (714 kB)
Supplementary file 4 DEseq output of in vitro rhamnose-exposed C difficile transcriptomic profiling.
elife-72801-transrepform1-v1.pdf (336 kB)
Transparent reporting form
