Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma

Authors

Richa Rathore, Washington University School of Medicine in St. Louis
Katharine E Caldwell, Washington University School of Medicine in St. Louis
Charles Schutt, Washington University School of Medicine in St. Louis
Caitlyn B Brashears, Washington University School of Medicine in St. Louis
Bethany C Prudner, Washington University School of Medicine in St. Louis
William R Ehrhardt, Washington University School of Medicine in St. Louis
Cheuk Hong Leung, University of Texas MD Anderson Cancer Center
Heather Lin, University of Texas MD Anderson Cancer Center
Najat C Daw, University of Texas MD Anderson Cancer Center
Hannah C Beird, University of Texas MD Anderson Cancer Center
Abigail Giles, Washington University School of Medicine in St. Louis
Wei-Lien Wang, University of Texas MD Anderson Cancer Center
Alexander J Lazar, University of Texas MD Anderson Cancer Center
John S A Chrisinger, Washington University School of Medicine in St. Louis
J Andrew Livingston, The University of Texas MD Anderson Cancer Center
Brian A Van Tine, Washington University School of Medicine in St. Louis

Journal

Cell Reports

Publication Date

1-26-2021

Volume

34

Issue

4

First Page

108678

Document Type

Open Access Publication

DOI

10.1016/j.celrep.2020.108678

Rights and Permissions

Rathore R, Caldwell KE, Schutt C, Brashears CB, Prudner BC, Ehrhardt WR, Leung CH, Lin H, Daw NC, Beird HC, Giles A, Wang WL, Lazar AJ, Chrisinger JSA, Livingston JA, Van Tine BA. Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma. Cell Rep. 2021 Jan 26;34(4):108678. doi: 10.1016/j.celrep.2020.108678. Copyright 2020 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Recommended Citation

Rathore, Richa; Caldwell, Katharine E; Schutt, Charles; Brashears, Caitlyn B; Prudner, Bethany C; Ehrhardt, William R; Leung, Cheuk Hong; Lin, Heather; Daw, Najat C; Beird, Hannah C; Giles, Abigail; Wang, Wei-Lien; Lazar, Alexander J; Chrisinger, John S A; Livingston, J Andrew; and Van Tine, Brian A, "Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma." Cell Reports. 34, 4. 108678 (2021).
https://digitalcommons.wustl.edu/open_access_pubs/11289