Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase

Authors

Joshua B Radke, Washington University School of Medicine in St. Louis
Bruno Melillo, The Scripps Research Institute
Payal Mittal, International Centre for Genetic Engineering and Biotechnology
Manmohan Sharma, International Centre for Genetic Engineering and Biotechnology
Amit Sharma, International Centre for Genetic Engineering and Biotechnology
Yong Fu, Washington University School of Medicine in St. Louis
Taher Uddin, Washington University School of Medicine in St. Louis
Arthur Gonse, Broad Institute
Eamon Comer, Broad Institute
Stuart L Schreiber, Harvard University
Anil K Gupta, The Scripps Research Institute
Arnab K Chatterjee, The Scripps Research Institute
L David Sibley, Washington University School of Medicine in St. Louis

Journal

Nature Communications

Publication Date

1-24-2022

Volume

13

Issue

1

First Page

459

Document Type

Open Access Publication

DOI

10.1038/s41467-022-28108-y

Rights and Permissions

Radke JB, Melillo B, Mittal P, Sharma M, Sharma A, Fu Y, Uddin T, Gonse A, Comer E, Schreiber SL, Gupta AK, Chatterjee AK, Sibley LD. Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase. Nat Commun. 2022 Jan 24;13(1):459. doi: 10.1038/s41467-022-28108-y. https://www.nature.com/articles/s41467-022-28108-y This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Recommended Citation

Radke, Joshua B; Melillo, Bruno; Mittal, Payal; Sharma, Manmohan; Sharma, Amit; Fu, Yong; Uddin, Taher; Gonse, Arthur; Comer, Eamon; Schreiber, Stuart L; Gupta, Anil K; Chatterjee, Arnab K; and Sibley, L David, "Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase." Nature Communications. 13, 1. 459 (2022).
https://digitalcommons.wustl.edu/open_access_pubs/11343