Journal
Elife
Publication Date
2022
Volume
11
First Page
e70173
Document Type
Open Access Publication
DOI
10.7554/eLife.70173
Rights and Permissions
eLife 2022;11:e70173 DOI: 10.7554/eLife.70173. © 2022, Ransdell et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Ransdell, Joseph L.; Moreno, Jonathan D.; Bhagavan, Druv; Silva, Jonathan R.; and Nerbonne, Jeanne M., "Intrinsic mechanisms in the gating of resurgent Na+ currents." Elife. 11, e70173 (2022).
https://digitalcommons.wustl.edu/open_access_pubs/11409
Figures and figure supplements.pdf (4280 kB)
elife-70173-sa2-fig1-v2.jpg (20 kB)
Author response image 1. Simulations of INaR following membrane depolarizations to different voltages using the open-blocked model. Left: voltage protocol indicating a 0 mV (black), -15 mV (blue), -30 mV (red), -45 mV (green) depolarization for 5 ms from a membrane potential of -90 mV. Middle: Simulated Nav current traces. Right: A zoomed in view of the simulated Nav currents reveals that the open-blocked model produces resurgent currents quite different from those observed experimentally (Figure 2A); compare with the results of the novel model generated here (Figure 3I). Additionally, INaR inactivation in this (open-blocked) model appears to show some voltage dependence, which is also not observed in our model (Figure 3I).
elife-70173-sa2-fig2-v2.jpg (64 kB)
Author response image 2
elife-70173-transrepform1-v2.pdf (211 kB)
Transparent reporting form
elife-70173-sa2-fig1-v2.jpg (20 kB)
Author response image 1. Simulations of INaR following membrane depolarizations to different voltages using the open-blocked model. Left: voltage protocol indicating a 0 mV (black), -15 mV (blue), -30 mV (red), -45 mV (green) depolarization for 5 ms from a membrane potential of -90 mV. Middle: Simulated Nav current traces. Right: A zoomed in view of the simulated Nav currents reveals that the open-blocked model produces resurgent currents quite different from those observed experimentally (Figure 2A); compare with the results of the novel model generated here (Figure 3I). Additionally, INaR inactivation in this (open-blocked) model appears to show some voltage dependence, which is also not observed in our model (Figure 3I).
elife-70173-sa2-fig2-v2.jpg (64 kB)
Author response image 2
elife-70173-transrepform1-v2.pdf (211 kB)
Transparent reporting form
