Journal
Molecular Psychiatry
Publication Date
2-1-2021
Volume
26
Issue
9
First Page
4884
Last Page
4895
Document Type
Open Access Publication
DOI
10.1038/s41380-021-01026-z
Rights and Permissions
Saarentaus, E.C., Havulinna, A.S., Mars, N. et al. Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants. Mol Psychiatry 26, 4884–4895 (2021). doi.org/10.1038/s41380-021-01026-z Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Recommended Citation
Saarentaus, Elmo Christian; Chen, Lei; Hall, Ira M; and et al, "Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants." Molecular Psychiatry. 26, 9. 4884 - 4895. (2021).
https://digitalcommons.wustl.edu/open_access_pubs/11707
Supplemental Material Documentation
41380_2021_1026_MOESM2_ESM.pdf (411 kB)
Supplementary Table 1: Counts and Frequencies of Phenotype-associated CNVs in FINRISK and NFBC
41380_2021_1026_MOESM3_ESM.xlsx (9 kB)
Supplementary Table 2: Disease endpoints considered
41380_2021_1026_MOESM4_ESM.pdf (606 kB)
Supplementary Table 3: DECIPHER disease-associated CNV regions and frequencies
41380_2021_1026_MOESM5_ESM.pdf (402 kB)
Supplementary Table 4: Charlson Comorbidity Phenotypes
41380_2021_1026_MOESM6_ESM.xlsx (11 kB)
Supplementary Table 5: Socioeconomic status groupings
41380_2021_1026_MOESM7_ESM.pdf (5 kB)
Supplementary Figure 1: Correlation between neuropsychiatric disorders in FINRISK
41380_2021_1026_MOESM8_ESM.pdf (9 kB)
Supplementary Figure 2: Meta-analysis of SNPD association with CNV subgroups
41380_2021_1026_MOESM9_ESM.pdf (7 kB)
Supplementary Figure 3: SNPD association with CNV subgroups in FINRISK
41380_2021_1026_MOESM10_ESM.pdf (7 kB)
Supplementary Figure 4: SNPD association with CNV subgroups in NFBC
41380_2021_1026_MOESM11_ESM.pdf (4 kB)
Supplementary Figure 5: Spearman’s correlation between categorical socioeconomic endpoints in FINRISK
41380_2021_1026_MOESM12_ESM.pdf (7 kB)
Supplementary Figure 6: Meta-analysis of level of household income in CNV subgroups
41380_2021_1026_MOESM13_ESM.pdf (5 kB)
Supplementary Figure 7: Subjective health in different CNV subgroups in NFBC
41380_2021_1026_MOESM14_ESM.pdf (5 kB)
Supplementary Figure 8: Subjective health in different CNV subgroups in FINRISK
41380_2021_1026_MOESM15_ESM.pdf (5 kB)
Supplementary Figure 9: Charlson Comorbidity Index in different CNV subgroups in FINRISK
41380_2021_1026_MOESM16_ESM.pdf (7 kB)
Supplementary Figure 10: Meta-analysis of impact of high-risk CNVs and PRS outlier status on socioeconomic grouping
41380_2021_1026_MOESM17_ESM.jpg (91 kB)
Supplementary Figure 11: PRS_EA distribution in FINRISK CNV carriers vs non-carriers not affected by SNPD, by level of education
41380_2021_1026_MOESM18_ESM.jpg (99 kB)
Supplementary Figure 12: PRS_EA distribution in FINRISK CNV carriers vs non-carriers not affected by SNPD, by years of education
