Journal
Elife
Publication Date
2022
Volume
11
First Page
e75753
Document Type
Open Access Publication
DOI
10.7554/eLife.75753
Rights and Permissions
Sun K, Wang C, Xiao J, Brodt MD, Yuan L, Yang T, Alippe Y, Hu H, Hao D, Abu-Amer Y, Silva MJ, Shen J, Mbalaviele G. Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling. Elife. 2022 Mar 4;11:e75753. doi.org/10.7554/eLife.75753. © 2022, Sun et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Sun, Kai; Wang, Chun; Xiao, Jianqiu; Brodt, Michael D.; Yuan, Luorongxin; Yang, Tong; Alippe, Yael; Hu, Huimin; Hao, Dingjun; Abu-Amer, Yousef; Silva, Matthew J.; Shen, Jie; and Mbalaviele, Gabriel, "Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling." Elife. 11, e75753 (2022).
https://digitalcommons.wustl.edu/open_access_pubs/11776
elife-75753-fig1-data1-v2.xlsx (10 kB)
Figure 1—source data 1 qPCR analysis of Gsdmd and Gsdme expression in bone marrow (BM) and BM-free tibias of wild-type (WT) and Gsdmd-/- mice.
elife-75753-fig1-data2-v2.zip (3805 kB)
Figure 1—source data 2 Western blots for Figure 1.
elife-75753-fig1-data3-v2.xlsx (8 kB)
Figure 1—source data 3 Bone callus volume of wild-type (WT), Gsdmd-/-, Gsdme-/-, and Gsdmd-/-;Gsdme-/- mice.
elife-75753-fig2-data1-v2.xlsx (11 kB)
Figure 2—source data 1 Micro-computed tomography (µCT) and histological, and histomorphometric analyses of wild-type (WT) and Gsdmd-/- mice.
elife-75753-fig3-data1-v2.xlsx (9 kB)
Figure 3—source data 1 Biomechanical analysis of wild-type (WT) and Gsdmd-/- mice.
elife-75753-fig4-data1-v2.xlsx (10 kB)
Figure 4—source data 1 ELISA analysis of interleukin-1β (IL-1β) and IL-18 levels in bone marrow (BM) supernatants of wild-type (WT) and Gsdmd-/- mice.
elife-75753-fig4-data2-v2.xlsx (9 kB)
Figure 4—source data 2 qPCR analysis of gene expression in bone marrow (BM) and BM-free tibias of wild-type (WT) and Gsdmd-/- mice.
elife-75753-fig5-data1-v2.xlsx (11 kB)
Figure 5—source data 1 ELISA analysis of interleukin-1β (IL-1β) and IL-18 levels in wild-type (WT) and Gsdmd-/- cell culture supernatants.
elife-75753-fig5-data2-v2.zip (4946 kB)
Figure 5—source data 2 Micro-computed tomography (µCT) and histological, and histomorphometric analyses of wild-type (WT) and Il-1r-/- mice.
elife-75753-fig6-data1-v2.xlsx (10 kB)
Figure 6—source data 1 Callus parameters of WT and Il1r-/- mice.
elife-75753-transrepform1-v2.pdf (698 kB)
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