Journal
Acta Neuropathologica Communications
Publication Date
3-24-2022
Volume
10
Issue
1
First Page
38
Document Type
Open Access Publication
DOI
10.1186/s40478-022-01347-2
Rights and Permissions
Smyth, L.C.D., Murray, H.C., Hill, M. et al. Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease. acta neuropathol commun 10, 38 (2022). doi.org/1This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.0.1186/s40478-022-01347-2
Recommended Citation
Smyth, Leon C D and et al, "Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease." Acta Neuropathologica Communications. 10, 1. 38 (2022).
https://digitalcommons.wustl.edu/open_access_pubs/11838
Figure S1: MPO labelling is predominantly confined to neutrophils. Figure S2: Neutrophil accumulation is independent of sex, age, and post-mortem delay. Figure S3: Regional analysis of neutrophil accumulation in APP/PS1 mice. Figure S4: Amyloid-β1-42 does not induce NETosis in vitro. Figure S5: Specificity of antibody labelling across multiple rounds of multiplexed immunohistochemistry. Table S1: Case details of tissue used in tissue microarray and immunohistochemistry experiments. Table S2: Details of antibodies used for these studies.
